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- W1517330054 abstract "Optical microscopy is an imaging technique that allowsmorphological mapping of intracellular structures with submicronresolution. More importantly, optical microscopy is a techniquethat can readily provide images with biochemical contrast based ondifferent spectroscopic modalities such as fluorescence spectrumand lifetime, Raman spectrum, optical polarization and phase.Although, optical microscopy can provide superior resolution overmany other medical imaging modalities such as MRI, CT orultrasound, the relatively low throughput limits its range ofbiomedical application. In this thesis, high throughput 3D opticalimaging instruments have been developed for medical and biologicalapplications based on widefield 3D resolved techniques. First, wedeveloped a high throughput depth resolved widefield imagecytometer based on the structured light illumination and the highspeed remote depth scanning. This system improves imagingthroughput by an order of magnitude over the current technology andcan potentially be applied to image cytometry investigation tostudy cultured cell morphologies with statistical significancecomparable to the flow cytometer. The statistical accuracy of thisinstrument is verified by quantitatively measuring the rare cellpopulations. Hyperspectral imaging is also possible based on theuse of an interferometric full field spectrometer. Second, wedeveloped a depth resolved widefield two photon endomicroscope forthe medical diagnosis based on the temporally focused widefield twophoton microscopy. The developed instrument can parallelize theimage acquisition process over the whole field of view without theneed for any scanning mechanism at the distal end of the opticalfiber. The method for delivering high peak power laser pulsesthrough the optical fiber has been proposed to improve the signalto noise ratio which in turn improves the imaging throughput. Astructured light illumination method have also been proposed anddemonstrated for improving depth resolution. In addition, thistemporally focused widefield two photon microscopy has been appliedto the high throughput depth resolved measurement of fluorescenceand phosphorescence lifetime with millisecond level framerate." @default.
- W1517330054 created "2016-06-24" @default.
- W1517330054 creator A5032714674 @default.
- W1517330054 date "2014-01-01" @default.
- W1517330054 modified "2023-09-26" @default.
- W1517330054 title "High throughput 3D optical microscopy : from image cytometry to endomicroscopy" @default.
- W1517330054 hasPublicationYear "2014" @default.
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