Matches in SemOpenAlex for { <https://semopenalex.org/work/W1517339982> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W1517339982 endingPage "65.18" @default.
- W1517339982 startingPage "65.18" @default.
- W1517339982 abstract "Abstract NKT cells are thymus-generated T lineage cells with shared phenotypic and functional characteristics of innate NK cells. Both T and NK cells require γc cytokines for their survival and homeostasis with T cells being dependent on IL-7 while NK cells being dependent on IL-15. As NKT cells carry features of both T and NK cells, it has been a long standing question which γc cytokine would drive the survival and homeostasis of NKT cells. In contrast to the current view, here we report that NKT cells survival is not dependent on IL-15 but requires IL-7. Specifically, we found that IL-15-deficient mice have intact numbers of peripheral NKT cells and that overexpression of IL-15 failed to expand NKT cell numbers even as it significantly increased CD8 T cell numbers. On the other hand, using a new in vivo model of IL-7-deficiency selectively in peripheral lymphoid tissues (K7 mice), we demonstrated that IL-7 is a non-redundant survival factor for NKT cells. Furthermore, transgenic IL-7 expression dramatically increased peripheral NKT cell numbers, suggesting that IL-7 availability determines size of the NKT cell pool. Mechanistically, we identified STAT5 as the transcriptional effector molecule downstream of IL-7 signaling to promote survival and maintain NKT cell homeostasis. Collectively, these data provide a new perspective on γc cytokine requirements for NKT cell survival, proposing a new role for IL-7 in NKT cell biology." @default.
- W1517339982 created "2016-06-24" @default.
- W1517339982 creator A5005423984 @default.
- W1517339982 creator A5015519992 @default.
- W1517339982 creator A5022278226 @default.
- W1517339982 creator A5047445678 @default.
- W1517339982 date "2014-05-01" @default.
- W1517339982 modified "2023-09-27" @default.
- W1517339982 title "NKT cells require IL-7, not IL-15, for survival and homeostasis (LYM4P.761)" @default.
- W1517339982 doi "https://doi.org/10.4049/jimmunol.192.supp.65.18" @default.
- W1517339982 hasPublicationYear "2014" @default.
- W1517339982 type Work @default.
- W1517339982 sameAs 1517339982 @default.
- W1517339982 citedByCount "1" @default.
- W1517339982 countsByYear W15173399822022 @default.
- W1517339982 crossrefType "journal-article" @default.
- W1517339982 hasAuthorship W1517339982A5005423984 @default.
- W1517339982 hasAuthorship W1517339982A5015519992 @default.
- W1517339982 hasAuthorship W1517339982A5022278226 @default.
- W1517339982 hasAuthorship W1517339982A5047445678 @default.
- W1517339982 hasConcept C136449434 @default.
- W1517339982 hasConcept C139563560 @default.
- W1517339982 hasConcept C167672396 @default.
- W1517339982 hasConcept C203014093 @default.
- W1517339982 hasConcept C2778690821 @default.
- W1517339982 hasConcept C47742525 @default.
- W1517339982 hasConcept C63645605 @default.
- W1517339982 hasConcept C74172505 @default.
- W1517339982 hasConcept C86803240 @default.
- W1517339982 hasConcept C8891405 @default.
- W1517339982 hasConcept C95444343 @default.
- W1517339982 hasConcept C98119934 @default.
- W1517339982 hasConceptScore W1517339982C136449434 @default.
- W1517339982 hasConceptScore W1517339982C139563560 @default.
- W1517339982 hasConceptScore W1517339982C167672396 @default.
- W1517339982 hasConceptScore W1517339982C203014093 @default.
- W1517339982 hasConceptScore W1517339982C2778690821 @default.
- W1517339982 hasConceptScore W1517339982C47742525 @default.
- W1517339982 hasConceptScore W1517339982C63645605 @default.
- W1517339982 hasConceptScore W1517339982C74172505 @default.
- W1517339982 hasConceptScore W1517339982C86803240 @default.
- W1517339982 hasConceptScore W1517339982C8891405 @default.
- W1517339982 hasConceptScore W1517339982C95444343 @default.
- W1517339982 hasConceptScore W1517339982C98119934 @default.
- W1517339982 hasIssue "1_Supplement" @default.
- W1517339982 hasLocation W15173399821 @default.
- W1517339982 hasOpenAccess W1517339982 @default.
- W1517339982 hasPrimaryLocation W15173399821 @default.
- W1517339982 hasRelatedWork W1552034171 @default.
- W1517339982 hasRelatedWork W2012302863 @default.
- W1517339982 hasRelatedWork W2076943072 @default.
- W1517339982 hasRelatedWork W2749345046 @default.
- W1517339982 hasRelatedWork W2884845863 @default.
- W1517339982 hasRelatedWork W2944325699 @default.
- W1517339982 hasRelatedWork W3184533981 @default.
- W1517339982 hasRelatedWork W3189403816 @default.
- W1517339982 hasRelatedWork W4313356886 @default.
- W1517339982 hasRelatedWork W33640950 @default.
- W1517339982 hasVolume "192" @default.
- W1517339982 isParatext "false" @default.
- W1517339982 isRetracted "false" @default.
- W1517339982 magId "1517339982" @default.
- W1517339982 workType "article" @default.