FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1517340965> ?p ?o ?g. }

• W1517340965 endingPage "7488" @default.
• W1517340965 startingPage "7482" @default.
• W1517340965 abstract "We have found that synthesis of the 78-kDa glucose-regulated protein, GRP78, was increased following glucocorticoid treatment of S49 and W7MG1 mouse lymphoma cell lines. These lines synthesized a 74-kDa mouse mammary tumor virus envelope glycoprotein precursor, Pr74, both constitutively and in response to glucocorticoid treatment. In these cell lines, nascent Pr74 was not processed normally but was retained within the endoplasmic reticulum where it was bound stably by GRP78. GRP78 synthesis was not increased following glucocorticoid treatment of the W7.2 mouse lymphoma cell line, which does not synthesize Pr74, suggesting that the increase in GRP78 synthesis following glucocorticoid treatment of S49 and W7MG1 cells was secondary to the glucocorticoid-induced increase in Pr74 synthesis. Consistent with this hypothesis, the glucocorticoid-induced increase in Pr74 synthesis preceded the increase in GRP78 synthesis. Also, there was a direct correlation between the level of GRP78 synthesis and the level of Pr74 synthesis among multiple subclones of the W7-ENV/N line. This line was derived from the W7.2 line by retroviral mediated transfer of a constitutively expressed sequence encoding a defective form of Pr74 that was bound stably by GRP78 within the endoplasmic reticulum. An elevation in the steady state level of GRP78 mRNA was not detected either in glucocorticoid-treated S49 cells and W7MG1 cells or in subclones of the W7-ENV/N line that have an increased level of GRP78 synthesis. Therefore, it appears that the binding of Pr74 to GRP78 induces an increase in GRP78 synthesis that is regulated at a translational level, rather than at a transcriptional level." @default.
• W1517340965 created "2016-06-24" @default.
• W1517340965 creator A5030489938 @default.
• W1517340965 creator A5038137463 @default.
• W1517340965 creator A5045643507 @default.
• W1517340965 creator A5072250713 @default.
• W1517340965 creator A5085124229 @default.
• W1517340965 date "1993-04-01" @default.
• W1517340965 modified "2023-10-18" @default.
• W1517340965 title "Relationship between defective mouse mammary tumor virus envelope glycoprotein synthesis and GRP78 synthesis in glucocorticoid-treated mouse lymphoma cells. Evidence for translational control of GRP78 synthesis." @default.
• W1517340965 cites W1486906704 @default.
• W1517340965 cites W1495548641 @default.
• W1517340965 cites W1497407086 @default.
• W1517340965 cites W1504266925 @default.
• W1517340965 cites W1531083656 @default.
• W1517340965 cites W1534485329 @default.
• W1517340965 cites W1536942450 @default.
• W1517340965 cites W1538657525 @default.
• W1517340965 cites W1605456662 @default.
• W1517340965 cites W1614185919 @default.
• W1517340965 cites W1639558802 @default.
• W1517340965 cites W1762774688 @default.
• W1517340965 cites W1919835673 @default.
• W1517340965 cites W1963909878 @default.
• W1517340965 cites W1969419906 @default.
• W1517340965 cites W1971140237 @default.
• W1517340965 cites W1976137274 @default.
• W1517340965 cites W1978197479 @default.
• W1517340965 cites W1980669547 @default.
• W1517340965 cites W1999719904 @default.
• W1517340965 cites W2002733795 @default.
• W1517340965 cites W2005646330 @default.
• W1517340965 cites W2017356464 @default.
• W1517340965 cites W2020437934 @default.
• W1517340965 cites W2035826838 @default.
• W1517340965 cites W2036326457 @default.
• W1517340965 cites W2037044371 @default.
• W1517340965 cites W2041503025 @default.
• W1517340965 cites W2051793369 @default.
• W1517340965 cites W2055533988 @default.
• W1517340965 cites W2060333964 @default.
• W1517340965 cites W2062947011 @default.
• W1517340965 cites W2075507370 @default.
• W1517340965 cites W2088283936 @default.
• W1517340965 cites W2092198909 @default.
• W1517340965 cites W2100837269 @default.
• W1517340965 cites W2104755183 @default.
• W1517340965 cites W2115397055 @default.
• W1517340965 cites W2135214524 @default.
• W1517340965 cites W2156759984 @default.
• W1517340965 cites W2158636606 @default.
• W1517340965 cites W2164179462 @default.
• W1517340965 cites W2175307231 @default.
• W1517340965 cites W2176061808 @default.
• W1517340965 cites W2344103177 @default.
• W1517340965 cites W2401854877 @default.
• W1517340965 cites W4251499038 @default.
• W1517340965 doi "https://doi.org/10.1016/s0021-9258(18)53200-2" @default.
• W1517340965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8385109" @default.
• W1517340965 hasPublicationYear "1993" @default.
• W1517340965 type Work @default.
• W1517340965 sameAs 1517340965 @default.
• W1517340965 citedByCount "16" @default.
• W1517340965 countsByYear W15173409652015 @default.
• W1517340965 countsByYear W15173409652021 @default.
• W1517340965 crossrefType "journal-article" @default.
• W1517340965 hasAuthorship W1517340965A5030489938 @default.
• W1517340965 hasAuthorship W1517340965A5038137463 @default.
• W1517340965 hasAuthorship W1517340965A5045643507 @default.
• W1517340965 hasAuthorship W1517340965A5072250713 @default.
• W1517340965 hasAuthorship W1517340965A5085124229 @default.
• W1517340965 hasBestOaLocation W15173409651 @default.
• W1517340965 hasConcept C108625454 @default.
• W1517340965 hasConcept C126322002 @default.
• W1517340965 hasConcept C134018914 @default.
• W1517340965 hasConcept C153911025 @default.
• W1517340965 hasConcept C159047783 @default.
• W1517340965 hasConcept C2522874641 @default.
• W1517340965 hasConcept C2779338263 @default.
• W1517340965 hasConcept C2779777497 @default.
• W1517340965 hasConcept C2780841215 @default.
• W1517340965 hasConcept C3675279 @default.
• W1517340965 hasConcept C71924100 @default.
• W1517340965 hasConcept C86803240 @default.
• W1517340965 hasConcept C95444343 @default.
• W1517340965 hasConceptScore W1517340965C108625454 @default.
• W1517340965 hasConceptScore W1517340965C126322002 @default.
• W1517340965 hasConceptScore W1517340965C134018914 @default.
• W1517340965 hasConceptScore W1517340965C153911025 @default.
• W1517340965 hasConceptScore W1517340965C159047783 @default.
• W1517340965 hasConceptScore W1517340965C2522874641 @default.
• W1517340965 hasConceptScore W1517340965C2779338263 @default.
• W1517340965 hasConceptScore W1517340965C2779777497 @default.
• W1517340965 hasConceptScore W1517340965C2780841215 @default.
• W1517340965 hasConceptScore W1517340965C3675279 @default.
• W1517340965 hasConceptScore W1517340965C71924100 @default.
• W1517340965 hasConceptScore W1517340965C86803240 @default.
• W1517340965 hasConceptScore W1517340965C95444343 @default.

• next