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• W151735344 abstract "This chapter provides an overview of the pharmacology of B1 receptors. The ability of the nonapeptide, bradykinin (BK), to elicit pain, inflammation, and smooth muscle contraction was described initially by Rocha e Silva et al. Subsequent pharmacological studies discussed in the chapter suggest that at least two receptor subtypes, B1 and B2, mediate the biological actions of the kinins. The tools of molecular biology have been responsible for several recent advances in the understanding of the sequence and pharmacology of kinin receptors. The molecular cloning of B1 and B2 receptors has revealed them to be members of the superfamily of G protein-coupled receptors. Cloning and pharmacological characterization of B1 receptors has demonstrated that there are species differences in the affinities of B1 receptors for different agonists. Similarly, the molecular cloning and characterization of B2 receptors indicate species differences with respect to antagonist effects and which may account for some of the pharmacological data previously suggestive of receptor subtypes. The targeted disruption of the gene encoding the mouse B2 receptor provides direct evidence for a single B2 receptor subtype in smooth muscle and neuronal tissues of these species." @default.
• W151735344 created "2016-06-24" @default.
• W151735344 creator A5012656530 @default.
• W151735344 date "1997-01-01" @default.
• W151735344 modified "2023-10-15" @default.
• W151735344 title "Molecular Pharmacology of Kinin Receptors" @default.
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• W151735344 doi "https://doi.org/10.1016/b978-012249340-9/50005-x" @default.
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