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• W1517423134 abstract "Intravenous cholecystokinin octapeptide (CCK-8) elicits vago-vagal reflexes that inhibit phasic gastric contractions and reduce gastric tone in urethane-anaesthetized rats. A discrete proximal subdivision of the ventral gastric vagus nerve (pVGV) innervates the proximal stomach, but the fibre populations within it have not been characterized previously.We hypothesized that I.V. CCK-8 injection would excite inhibitory efferent outflow in the pVGV, in contrast to its inhibitory effect on excitatory efferent outflow in the distal subdivision (dVGV), which supplies the distal stomach. In each VGV subdivision, a dual-recording technique was used to record afferent and efferent activity simultaneously, while also monitoring intragastric pressure (IGP). CCK-8 dose dependently (100-1000 pmol kg(-1), I.V.) reduced gastric tone, gastric contractile activity and multi-unit dVGV efferent discharge, but increased pVGV efferent firing. Single-unit analysis revealed a minority of efferent fibres in each branch whose response differed in direction from the bulk response. Unexpectedly, efferent excitation in the pVGV was significantly shorter lived and had a significantly shorter decay half-time than did efferent inhibition in the dVGV, indicating that distinct pathways drive CCK-evoked outflow to the proximal vs. the distal stomach. Efferent inhibition in the dVGV began several seconds before, and persisted significantly longer than, simultaneously recorded dVGV afferent excitation.Thus, dVGV afferent excitation could not account for the pattern of dVGV efferent inhibition. However, the time course of dVGV afferent excitation paralleled that of pVGV efferent excitation. Similarly, the duration of CCK-8-evoked afferent responses recorded in the accessory celiac branch of the vagus (ACV) matched the duration of dVGV efferent responses. The observed temporal relationships suggest that postprandial effects on gastric complicance of CCK released from intestinal endocrine cells may require circulating concentrations to rise to levels capable of exciting distal gastric afferent fibres, in contrast to more immediate effects on distal gastric contractile activity mediated via vago-vagal reflexes initiated by paracrine excitation of intestinal afferents." @default.
• W1517423134 created "2016-06-24" @default.
• W1517423134 creator A5010241733 @default.
• W1517423134 creator A5037645081 @default.
• W1517423134 creator A5063974264 @default.
• W1517423134 creator A5072923374 @default.
• W1517423134 date "2011-01-14" @default.
• W1517423134 modified "2023-09-27" @default.
• W1517423134 title "Electrophysiological evidence for distinct vagal pathways mediating CCK-evoked motor effects in the proximal<i>versus</i>distal stomach" @default.
• W1517423134 cites W1429789039 @default.
• W1517423134 cites W1519523373 @default.
• W1517423134 cites W152256931 @default.
• W1517423134 cites W1559617572 @default.
• W1517423134 cites W1598367285 @default.
• W1517423134 cites W1600349900 @default.
• W1517423134 cites W1618681344 @default.
• W1517423134 cites W1646318902 @default.
• W1517423134 cites W1653935866 @default.
• W1517423134 cites W1889789606 @default.
• W1517423134 cites W1921911072 @default.
• W1517423134 cites W1924274190 @default.
• W1517423134 cites W1924718359 @default.
• W1517423134 cites W1928410833 @default.
• W1517423134 cites W1964803256 @default.
• W1517423134 cites W1966989999 @default.
• W1517423134 cites W1968019357 @default.
• W1517423134 cites W1968666385 @default.
• W1517423134 cites W1969103517 @default.
• W1517423134 cites W1971846763 @default.
• W1517423134 cites W1973772464 @default.
• W1517423134 cites W1974471078 @default.
• W1517423134 cites W1976240003 @default.
• W1517423134 cites W1976609043 @default.
• W1517423134 cites W1977717686 @default.
• W1517423134 cites W1980958661 @default.
• W1517423134 cites W1982564696 @default.
• W1517423134 cites W1985802417 @default.
• W1517423134 cites W1987871392 @default.
• W1517423134 cites W1989952505 @default.
• W1517423134 cites W1990672799 @default.
• W1517423134 cites W1994579791 @default.
• W1517423134 cites W2005830837 @default.
• W1517423134 cites W2005865101 @default.
• W1517423134 cites W2013766826 @default.
• W1517423134 cites W2021870404 @default.
• W1517423134 cites W2022454901 @default.
• W1517423134 cites W2024333046 @default.
• W1517423134 cites W2028442194 @default.
• W1517423134 cites W2032899100 @default.
• W1517423134 cites W2033002758 @default.
• W1517423134 cites W2038216497 @default.
• W1517423134 cites W2038915304 @default.
• W1517423134 cites W2046544883 @default.
• W1517423134 cites W2049206765 @default.
• W1517423134 cites W2058423368 @default.
• W1517423134 cites W2059067935 @default.
• W1517423134 cites W2060908841 @default.
• W1517423134 cites W2065345550 @default.
• W1517423134 cites W2066714304 @default.
• W1517423134 cites W2068382770 @default.
• W1517423134 cites W2069161138 @default.
• W1517423134 cites W2069404660 @default.
• W1517423134 cites W2071080566 @default.
• W1517423134 cites W2072474474 @default.
• W1517423134 cites W2079608193 @default.
• W1517423134 cites W2080975702 @default.
• W1517423134 cites W2081212065 @default.
• W1517423134 cites W2085104626 @default.
• W1517423134 cites W2085536990 @default.
• W1517423134 cites W2088886292 @default.
• W1517423134 cites W2091337796 @default.
• W1517423134 cites W2093331397 @default.
• W1517423134 cites W2104100416 @default.
• W1517423134 cites W2105616482 @default.
• W1517423134 cites W2106541451 @default.
• W1517423134 cites W2108670353 @default.
• W1517423134 cites W2110967609 @default.
• W1517423134 cites W2112949425 @default.
• W1517423134 cites W2114666737 @default.
• W1517423134 cites W2117104214 @default.
• W1517423134 cites W2123343463 @default.
• W1517423134 cites W2124644209 @default.
• W1517423134 cites W2131909679 @default.
• W1517423134 cites W2143133335 @default.
• W1517423134 cites W2155052320 @default.
• W1517423134 cites W2163918246 @default.
• W1517423134 cites W2166872095 @default.
• W1517423134 cites W2168994178 @default.
• W1517423134 cites W2170400159 @default.
• W1517423134 cites W2173564950 @default.
• W1517423134 cites W2182941164 @default.
• W1517423134 cites W2184677887 @default.
• W1517423134 cites W2209036429 @default.
• W1517423134 cites W2232115551 @default.
• W1517423134 cites W2256831100 @default.
• W1517423134 cites W2280349189 @default.
• W1517423134 cites W2281367791 @default.
• W1517423134 cites W2293210287 @default.

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