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- W1517426132 abstract "Berberis thunbergii var. atropurpurea. DC is one of the popular landscape plants in the USA, but until now lacked report on its chemical composition and biological properties. In this study, the antioxidant and anti-inflammatory activities of the methanolic extract and pure isolates of B. thunbergii var. atropurpurea, Crimson Pygmy, roots were evaluated using established bioassay procedures. The methanolic extract gave an absorbance value of 0.44 at 250 μg/mL concentration in the MTT assay. In addition, the extract inhibited lipid peroxidation (LPO) by 93% and the cyclooxygenase enzymes, COX-1 by 54 and COX-2 by 34%, at 100 μg/mL concentration. Therefore, a bioactivity-guided purification was carried out yielding pure isolates, out of which compounds 3-6 inhibited LPO by 34-66% at 100 μg/mL concentration. Similarly, compounds 1-6 inhibited COX-1 and −2 by 24-65 and 23-43% at 25 μg/mL concentration, respectively. This is the first report of the chemical constituents and biological activities of this plant." @default.
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- W1517426132 date "2013-02-01" @default.
- W1517426132 modified "2023-09-28" @default.
- W1517426132 title "Antioxidant and Anti-inflammatory Compounds in the Popular Landscape Plant <i>Berberis thunbergii</i> var. <i>atropurpurea</i>" @default.
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- W1517426132 doi "https://doi.org/10.1177/1934578x1300800207" @default.
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