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• W1517485745 abstract "Mammalian K + homeostasis results from highly regulated renal and intestinal absorption and secretion, which balances the unregulated K + intake. Aldosterone is known to enhance both renal and colonic K + secretion. In mouse distal colon K + secretion occurs exclusively via luminal K Ca 1.1 (BK) channels. Here we investigate if aldosterone stimulates colonic K + secretion via BK channels. Luminal Ba 2+ and iberiotoxin (IBTX)‐sensitive electrogenic K + secretion was measured in Ussing chambers. In vivo aldosterone was augmented via a high K + diet. High K + diet led to a 2‐fold increase of luminal Ba 2+ and IBTX‐sensitive short‐circuit current in distal mouse colonic mucosa. This effect was absent in BK α‐subunit‐deficient (BK −/− ) mice. The resting and diet‐induced K + secretion was stimulated by luminal ionomycin. In BK −/− mice luminal ionomycin did not stimulate K + secretion. In vitro addition of aldosterone likewise triggered a 2‐fold increase in K + secretion, which was inhibited by the mineralocorticoid receptor antagonist spironolactone and the BK channel blocker IBTX. Semi‐quantification of mRNA from colonic crypts showed up‐regulation of BK α‐ and β 2 ‐subunits in high K + diet mice. The BK channel could be detected luminally in colonic crypt cells by immunohistochemistry. The expression level of the channel in the luminal membrane was strongly up‐regulated in K + ‐loaded animals. Taken together, these data strongly suggest that aldosterone‐induced K + secretion occurs via increased expression of luminal BK channels." @default.
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• W1517485745 date "2008-09-01" @default.
• W1517485745 modified "2023-10-13" @default.
• W1517485745 title "Aldosterone increases K_Ca1.1 (BK) channel-mediated colonic K⁺secretion" @default.
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• W1517485745 doi "https://doi.org/10.1113/jphysiol.2008.156968" @default.
• W1517485745 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2652187" @default.
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