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• W1517503476 abstract "Complicate high-performance liquid chromatographic (HPLC) interfaces like the moving belt, direct liquid interface, thermospray (Arpino, 1985) fast atom bombardment (FAB) (Caprioli et al., 1986; Garcia & Barcelo, 1993; Dell et al., 1988; Larry et al., 1989) characterized the early days of HPLC used in tandem with mass-spectrometry (MS); all of them, apart FAB, were more effective with moderately polar compounds (Strege et al., 1999). After years of difficulties and struggles the introduction of atmospheric pressure ionization by electrospray (ESI) or chemical ionization marked a clear breakthrough: an effective, robust and user friendly HPLC interface was finally available. As a matter of fact, considering the physicochemical principles of the source, the polar compounds were the first compounds successfully ionized (Griffits, 2008). Despite the huge potential of ESI for polar and highly polar compounds the applications for the latter proved to be critical due to the fact that effective HPLC separations often require non volatile buffers and/or high water content that are not suitable in MS detection. Along the years, the development of HPLC columns, specific derivatization methods, new chromatographic techniques and sample preparation approaches have increased the number of applications with highly polar compounds. Three classes of not so widely studied molecules have been selected in this study in order to illustrate the application of HPLC-MS/MS to highly polar compounds; updates as well a review of past data will be presented. The groups of compounds taken in consideration are: glycosaminoglycans, bisphosphonates and amynoglycoside antibiotics; the first-ones are both endogenous and exogenous while the last 2 classes are of typical pharmaceutical interest. Obviously other more well–known molecules like peptides and polynucleotides are also included in this class of highly polar compounds but HPLC-MS/MS methods in these particular fields are widely described and probably represent the most common areas of application. It is also important to keep in mind that this chapter doesn’t intend to be an exhaustive presentation of the published analytical methods for heparins, bisphosphonates or aminoglycosides, but these compounds are used as models to emphasize the potential of HPLC-MS/MS in the analysis of highly polar molecules." @default.
• W1517503476 created "2016-06-24" @default.
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• W1517503476 date "2012-02-29" @default.
• W1517503476 modified "2023-10-04" @default.
• W1517503476 title "HPLC-MS/MS of Highly Polar Compounds" @default.
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• W1517503476 doi "https://doi.org/10.5772/33129" @default.
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