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• W1517522220 startingPage "1438" @default.
• W1517522220 abstract "The effects and signaling mechanisms of brain-derived neurotrophic factor (BDNF) on translation elongation were investigated in cortical neurons. BDNF increased the elongation rate approximately twofold, as determined by measuring the ribosomal transit time. BDNF-accelerated elongation was inhibited by rapamycin, implicating the mammalian target of rapamycin (mTOR). To explore the mechanisms underlying these effects, we examined the protein phosphorylation cascades that lead to the activation of translation elongation in neurons. BDNF increased eukaryote elongation factor 1A (eEF1A) phosphorylation and decreased eEF2 phosphorylation. Whereas eEF2 phosphorylation levels altered by BDNF were inhibited by rapamycin, eEF1A phosphorylation was not affected by rapamycin or PD98059, a mitogen-activated protein kinase kinase (MEK) inhibitor. BDNF induced phosphorylation of eEF2 kinase (Ser366), as well as decreased its kinase activity. All these events were inhibited by rapamycin. Furthermore, mTOR siRNA, which reduced mTOR levels up to 50%, inhibited the BDNF-induced enhancement in elongation rate and decrease in eEF2 phosphorylation. These results strongly suggest that BDNF enhances translation elongation through the activation of the mTOR–eEF2 pathway." @default.
• W1517522220 created "2016-06-24" @default.
• W1517522220 creator A5045161610 @default.
• W1517522220 creator A5047809277 @default.
• W1517522220 creator A5061069554 @default.
• W1517522220 date "2005-09-20" @default.
• W1517522220 modified "2023-09-23" @default.
• W1517522220 title "Enhancement of translation elongation in neurons by brain-derived neurotrophic factor: Implications for mammalian target of rapamycin signaling" @default.
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• W1517522220 doi "https://doi.org/10.1111/j.1471-4159.2005.03466.x" @default.
• W1517522220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16171514" @default.
• W1517522220 hasPublicationYear "2005" @default.
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