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- W1517551362 abstract "Chloroprocaine is a local ester anesthetic, producing excellent sensory block in clinical use. The Kv7/M potassium channel plays an important role in the control of neuronal excitability. In this study, we investigated the effects of the local anesthetic chloroprocaine on Kv7/M channels as well as the effect of retigabine on chloroprocaine-induced seizures.A perforated whole-cell patch technique was used to record Kv7 currents from HEK293 cells and M-type currents from rat dorsal root ganglion (DRG) neurons.Chloroprocaine produced a number of effects on Kv7.2/Kv7.3 currents, including a lowering of current amplitudes, a rightward shift in the voltage-dependent activation curves, and a slowing of channel activation. Chloroprocaine had a more selective inhibitory effect on the homomeric Kv7.3 and heteromeric Kv7.2/Kv7.3 channels than on the homomeric Kv7.2 channel. Chloroprocaine also inhibited native M channel currents and induced a depolarization of the DRG neuron membrane potential.Taken together, the findings indicate that chloroprocaine concentration dependently inhibited Kv7/M channel currents." @default.
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- W1517551362 date "2015-01-01" @default.
- W1517551362 modified "2023-09-22" @default.
- W1517551362 title "Inhibition of K<sub>v</sub>7/M Channel Currents by the Local Anesthetic Chloroprocaine" @default.
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- W1517551362 doi "https://doi.org/10.1159/000437231" @default.
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