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• W1517584908 abstract "Single-stranded circular DNA, containing the SV40 origin sequence, was used as a template for complementary DNA strand synthesis in cytosolic extracts from HeLa cells. In the presence of the replication-dependent chromatin assembly factor CAF-1, defined numbers of nucleosomes were assembled during complementary DNA strand synthesis. These minichromosomes were then induced to semiconservatively replicate by the addition of the SV40 initiator protein T antigen (re-replication). The results indicate that re-replication of minichromosomes appears to be inhibited by two independent mechanisms. One acts at the initiation of minichromosome re-replication, and the other affects replicative chain elongation. To directly demonstrate the inhibitory effect of replicatively assembled nucleosomes, two types of minichromosomes were prepared: (i) post-replicative minichromosomes were assembled in a reaction coupled to replication as above; (ii) pre-replicative minichromosomes were assembled independently of replication on double-stranded DNA. Both types of minichromosomes were used as templates for DNA replication under identical conditions. Replicative fork movement was found to be impeded only on post-replicative minichromosome templates. In contrast, pre-replicative minichromosomes allowed one unconstrained replication cycle, but re-replication was inhibited due to a block in fork movement. Thus, replicatively assembled chromatin may have a profound influence on the re-replication of DNA." @default.
• W1517584908 created "2016-06-24" @default.
• W1517584908 creator A5064742317 @default.
• W1517584908 creator A5068717323 @default.
• W1517584908 date "1994-08-01" @default.
• W1517584908 modified "2023-10-17" @default.
• W1517584908 title "Minichromosome replication in vitro: inhibition of re-replication by replicatively assembled nucleosomes." @default.
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• W1517584908 doi "https://doi.org/10.1016/s0021-9258(17)31924-5" @default.
• W1517584908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8063720" @default.
• W1517584908 hasPublicationYear "1994" @default.
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