Matches in SemOpenAlex for { <https://semopenalex.org/work/W1517691515> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1517691515 endingPage "2295" @default.
- W1517691515 startingPage "2291" @default.
- W1517691515 abstract "The importance of Ca++ in the initiation of lymphocyte activation and mitogenesis has been supported by several studies. Because calmodulin functions as the intracellular mediator of the effects of Ca++, it likely plays a major role in the regulation of lymphocyte function. We have examined the effects of known calmodulin antagonists, the phenothiazines, on lectin-induced T cell mitogenesis and have shown a central role for Ca++ uptake in the expression of a phenothiazine-sensitive stage after lectin activation. The drug effects were observed only if the cells were previously activated by PHA or the ionophore A23187, and only in the presence of Ca++. These effects were restricted to a defined time period (5 hr) after lectin activation. The data support the concept that calmodulin is the target for the phenothiazine effects and demonstrate the permissive role of Ca++ in the mediation of these events." @default.
- W1517691515 created "2016-06-24" @default.
- W1517691515 creator A5001784839 @default.
- W1517691515 creator A5023960478 @default.
- W1517691515 creator A5063705444 @default.
- W1517691515 date "1983-11-01" @default.
- W1517691515 modified "2023-09-27" @default.
- W1517691515 title "Permissive role of calcium in the inhibition of T cell mitogenesis by calmodulin antagonists." @default.
- W1517691515 doi "https://doi.org/10.4049/jimmunol.131.5.2291" @default.
- W1517691515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6415161" @default.
- W1517691515 hasPublicationYear "1983" @default.
- W1517691515 type Work @default.
- W1517691515 sameAs 1517691515 @default.
- W1517691515 citedByCount "31" @default.
- W1517691515 countsByYear W15176915152012 @default.
- W1517691515 countsByYear W15176915152022 @default.
- W1517691515 crossrefType "journal-article" @default.
- W1517691515 hasAuthorship W1517691515A5001784839 @default.
- W1517691515 hasAuthorship W1517691515A5023960478 @default.
- W1517691515 hasAuthorship W1517691515A5063705444 @default.
- W1517691515 hasBestOaLocation W15176915151 @default.
- W1517691515 hasConcept C178790620 @default.
- W1517691515 hasConcept C181080969 @default.
- W1517691515 hasConcept C181199279 @default.
- W1517691515 hasConcept C185592680 @default.
- W1517691515 hasConcept C2107291 @default.
- W1517691515 hasConcept C2775891158 @default.
- W1517691515 hasConcept C2779014961 @default.
- W1517691515 hasConcept C2780758401 @default.
- W1517691515 hasConcept C29688787 @default.
- W1517691515 hasConcept C519063684 @default.
- W1517691515 hasConcept C55493867 @default.
- W1517691515 hasConcept C79879829 @default.
- W1517691515 hasConcept C86803240 @default.
- W1517691515 hasConcept C95444343 @default.
- W1517691515 hasConceptScore W1517691515C178790620 @default.
- W1517691515 hasConceptScore W1517691515C181080969 @default.
- W1517691515 hasConceptScore W1517691515C181199279 @default.
- W1517691515 hasConceptScore W1517691515C185592680 @default.
- W1517691515 hasConceptScore W1517691515C2107291 @default.
- W1517691515 hasConceptScore W1517691515C2775891158 @default.
- W1517691515 hasConceptScore W1517691515C2779014961 @default.
- W1517691515 hasConceptScore W1517691515C2780758401 @default.
- W1517691515 hasConceptScore W1517691515C29688787 @default.
- W1517691515 hasConceptScore W1517691515C519063684 @default.
- W1517691515 hasConceptScore W1517691515C55493867 @default.
- W1517691515 hasConceptScore W1517691515C79879829 @default.
- W1517691515 hasConceptScore W1517691515C86803240 @default.
- W1517691515 hasConceptScore W1517691515C95444343 @default.
- W1517691515 hasIssue "5" @default.
- W1517691515 hasLocation W15176915151 @default.
- W1517691515 hasLocation W15176915152 @default.
- W1517691515 hasOpenAccess W1517691515 @default.
- W1517691515 hasPrimaryLocation W15176915151 @default.
- W1517691515 hasRelatedWork W1949746652 @default.
- W1517691515 hasRelatedWork W2010538547 @default.
- W1517691515 hasRelatedWork W2010735344 @default.
- W1517691515 hasRelatedWork W2013062802 @default.
- W1517691515 hasRelatedWork W2021364333 @default.
- W1517691515 hasRelatedWork W2037341853 @default.
- W1517691515 hasRelatedWork W2064093054 @default.
- W1517691515 hasRelatedWork W2086892519 @default.
- W1517691515 hasRelatedWork W2100044473 @default.
- W1517691515 hasRelatedWork W2416678573 @default.
- W1517691515 hasVolume "131" @default.
- W1517691515 isParatext "false" @default.
- W1517691515 isRetracted "false" @default.
- W1517691515 magId "1517691515" @default.
- W1517691515 workType "article" @default.