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• W1517698908 abstract "Bacterial signal peptides display little amino acid sequence homology despite their shared role in mediating protein transport. This heterogeneity may exist to permit the establishment of signal peptide conformations that are appropriate for transport of particular proteins. In this paper we explore how signal peptides are composed of structural units that may interact with each other and with the mature protein to effect transport. Using a new application of cassette mutagenesis, we have replaced the hydrophobic core of the Escherichia coli alkaline phosphatase signal peptide with cores from the signals of maltose-binding protein, OmpA, and M13 major coat protein. The core regions from maltose-binding protein and OmpA effectively replaced the alkaline phosphatase core; the resultant hybrid signals performed as well as wild type in periplasmic transport and processing of alkaline phosphatase. However, the core region from M13 major coat protein generated a transport-incompetent hybrid signal peptide. Elimination of a proline-containing portion of the M13 major coat protein core did not improve transport effectiveness. However, restoration of the procoat cleavage region and the negatively charged amino terminus of the mature protein did ameliorate the transport defect. These results suggest that at least in the case of these procoat-derived signal peptide mutants, there is a requirement for complementarity among the hydrophobic core, cleavage region, and part of the mature protein in order for efficient protein transport to occur." @default.
• W1517698908 created "2016-06-24" @default.
• W1517698908 creator A5030447237 @default.
• W1517698908 creator A5040538424 @default.
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• W1517698908 date "1989-08-01" @default.
• W1517698908 modified "2023-09-29" @default.
• W1517698908 title "Signal Peptide Subsegments Are Not Always Functionally Interchangeable" @default.
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• W1517698908 doi "https://doi.org/10.1016/s0021-9258(18)71703-1" @default.
• W1517698908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2668291" @default.
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