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- W1517751361 startingPage "1125" @default.
- W1517751361 abstract "Abstract The profound anemia of Diamond-Blackfan syndrome (DBS) is due to marrow red cell failure, but the pathogenesis is not understood. Studies by others indicated cell-mediated erythropoietic suppression in this condition. To explore this mechanism further, Ficoll-Hypaque--separated peripheral blood lymphocytes (PBL) from four anemic untreated patients with DBS, or from normals were cocultured with control marrow in vitro and the growth of erythropoietin-responsive stem cell colonies (CFU-E) was dermined. CFU-E numbers obtained from cultures with added normal PBL were not significantly different from the number without PBL. Similarly, CFU-E from cultures with added DBS PBL were not significantly different from the number without PBL (215 versus 220, 229 versus 220 and 84 versus 60, 74 versus 94/10(5) cells, respectively). Mixing marrows from a control and one DBS patient in ratios of 2:1, 1:1, or 1:2 prior to culture failed to disclose a decrease of colony growth. We could not show cellular inhibition of erythropoiesis in these patients with DBS. The mechanism of anemia in this disorder remains an open question." @default.
- W1517751361 created "2016-06-24" @default.
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- W1517751361 date "1978-06-01" @default.
- W1517751361 modified "2023-10-16" @default.
- W1517751361 title "Diamond-Blackfan syndrome: evidence against cell-mediated erythropoietic suppression" @default.
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- W1517751361 doi "https://doi.org/10.1182/blood.v51.6.1125.1125" @default.
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