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- W1517818058 abstract "Partial removal of monocytes from human peripheral blood mononuclear cells, or the addition of indomethacin. reduced the antiproliferative effect of 1,25(OH) 2 D 3 on mitogen‐stimulated mononuclear cells. Addition of 1,25(OH) 2 D 3 (1nM) to mitogen‐stimulated mononuclear cells caused a 2–4‐fold increase in prostaglandin E 2 production during the second day of culture. The inhibitory effect of 1,25(OH) 2 D 3 on lymphocyte proliferation is greatly augmented up to 7‐fold in the presence of prostaglandin E 2 . We conclude that monocytes are involved in the inhibitory effect of 1,25(OH) 2 D 3 on the mitogenic stimulation of human lymphocytes and that their action is probably mediated by prostaglandins." @default.
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- W1517818058 date "1986-09-01" @default.
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- W1517818058 title "1,25-Dihydroxyvitamin D<sub>3</sub> enhances prostaglandin E<sub>2</sub> production by monocytes" @default.
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- W1517818058 doi "https://doi.org/10.1016/0014-5793(86)80876-6" @default.
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