Matches in SemOpenAlex for { <https://semopenalex.org/work/W1517921313> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1517921313 abstract "Previous work suggests that elevations in oxidative stress are associated with cardiovascular disease. Although it is well known that oxidative stress increases with age, whether this occurs differently in men and women remains unclear. Likewise, recent work indicating that mRNA expression for NADPH oxidase is greater in peripheral blood mononuclear cells (PBMCs) of older subjects did not differentiate sex effects. Therefore, we measured plasma and intracellular levels of superoxide (O2●-), along with PBMC expression of NADPH oxidase subunits in 12 healthy older post-menopausal women and 10 age-matched older men. Older men demonstrated greater plasma O2●- levels (lucigenin chemiluminescence; men 202.73 ± 9.28 vs. women 171.67 ± 7.72, Relative Light Units; P<0.05) as well as intracellular O2●- in PBMCs (dihydroethidium fluorescence; men 1.94 ± 0.20 vs. women 0.96 ± 0.14, Relative Fluorescence Units; P<0.05) compared to older women. Similarly, western blot analysis demonstrated that older men exhibit greater NADPH oxidase subunit protein expression for gp91phox, p22phox, and p47phox in PBMCs (e.g., gp91phox; men 1.48 ± 0.38 vs. women 0.31 ± 0.07; P<0.05) and p67phox tended to be higher (P=0.14). These preliminary findings suggest that systemic O2●- levels are greater in older men compared to older women and PBMC-derived O2●- production via NADPH oxidase is a likely contributing source. Grant Funding Source: Supported by NIH R01 HL093167" @default.
- W1517921313 created "2016-06-24" @default.
- W1517921313 creator A5005065611 @default.
- W1517921313 creator A5006268607 @default.
- W1517921313 creator A5062302009 @default.
- W1517921313 date "2014-04-01" @default.
- W1517921313 modified "2023-09-24" @default.
- W1517921313 title "Sex influences systemic and peripheral blood mononuclear cell production of superoxide in older adults (1153.11)" @default.
- W1517921313 doi "https://doi.org/10.1096/fasebj.28.1_supplement.1153.11" @default.
- W1517921313 hasPublicationYear "2014" @default.
- W1517921313 type Work @default.
- W1517921313 sameAs 1517921313 @default.
- W1517921313 citedByCount "0" @default.
- W1517921313 crossrefType "journal-article" @default.
- W1517921313 hasAuthorship W1517921313A5005065611 @default.
- W1517921313 hasAuthorship W1517921313A5006268607 @default.
- W1517921313 hasAuthorship W1517921313A5062302009 @default.
- W1517921313 hasConcept C104317684 @default.
- W1517921313 hasConcept C126322002 @default.
- W1517921313 hasConcept C134018914 @default.
- W1517921313 hasConcept C137061746 @default.
- W1517921313 hasConcept C16685009 @default.
- W1517921313 hasConcept C181199279 @default.
- W1517921313 hasConcept C185592680 @default.
- W1517921313 hasConcept C202751555 @default.
- W1517921313 hasConcept C203014093 @default.
- W1517921313 hasConcept C2776151105 @default.
- W1517921313 hasConcept C2776415932 @default.
- W1517921313 hasConcept C2779719074 @default.
- W1517921313 hasConcept C2780795997 @default.
- W1517921313 hasConcept C2781308076 @default.
- W1517921313 hasConcept C48349386 @default.
- W1517921313 hasConcept C55493867 @default.
- W1517921313 hasConcept C71924100 @default.
- W1517921313 hasConcept C79879829 @default.
- W1517921313 hasConceptScore W1517921313C104317684 @default.
- W1517921313 hasConceptScore W1517921313C126322002 @default.
- W1517921313 hasConceptScore W1517921313C134018914 @default.
- W1517921313 hasConceptScore W1517921313C137061746 @default.
- W1517921313 hasConceptScore W1517921313C16685009 @default.
- W1517921313 hasConceptScore W1517921313C181199279 @default.
- W1517921313 hasConceptScore W1517921313C185592680 @default.
- W1517921313 hasConceptScore W1517921313C202751555 @default.
- W1517921313 hasConceptScore W1517921313C203014093 @default.
- W1517921313 hasConceptScore W1517921313C2776151105 @default.
- W1517921313 hasConceptScore W1517921313C2776415932 @default.
- W1517921313 hasConceptScore W1517921313C2779719074 @default.
- W1517921313 hasConceptScore W1517921313C2780795997 @default.
- W1517921313 hasConceptScore W1517921313C2781308076 @default.
- W1517921313 hasConceptScore W1517921313C48349386 @default.
- W1517921313 hasConceptScore W1517921313C55493867 @default.
- W1517921313 hasConceptScore W1517921313C71924100 @default.
- W1517921313 hasConceptScore W1517921313C79879829 @default.
- W1517921313 hasFunder F4320332161 @default.
- W1517921313 hasIssue "S1" @default.
- W1517921313 hasLocation W15179213131 @default.
- W1517921313 hasOpenAccess W1517921313 @default.
- W1517921313 hasPrimaryLocation W15179213131 @default.
- W1517921313 hasRelatedWork W1552796063 @default.
- W1517921313 hasRelatedWork W1989994240 @default.
- W1517921313 hasRelatedWork W2036801917 @default.
- W1517921313 hasRelatedWork W2090071726 @default.
- W1517921313 hasRelatedWork W2091918640 @default.
- W1517921313 hasRelatedWork W2107418117 @default.
- W1517921313 hasRelatedWork W2122655280 @default.
- W1517921313 hasRelatedWork W2158027695 @default.
- W1517921313 hasRelatedWork W2253391583 @default.
- W1517921313 hasRelatedWork W2353969029 @default.
- W1517921313 hasVolume "28" @default.
- W1517921313 isParatext "false" @default.
- W1517921313 isRetracted "false" @default.
- W1517921313 magId "1517921313" @default.
- W1517921313 workType "article" @default.