FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1517924874> ?p ?o ?g. }

• W1517924874 endingPage "28575" @default.
• W1517924874 startingPage "28569" @default.
• W1517924874 abstract "The cell-free immune repertoire of honeybees (Apis mellifera) consists of four polypeptides that are induced by bacterial infection and, through complementarity, provide broad-spectrum antibacterial defense. apidaecin is overproduced by a combination of low threshold transcriptional activation and a unique, genetically encoded amplification mechanism. In contrast, sizable experimental infections are required for induction of the normally silent hymenoptaecin, abaecin, and bee defensin genes; even so, bee defensin transcription is minimal and delayed, and only minute quantities of corresponding peptide are produced. The specific, temporal organization of the multi-component immune response in bees has therefore likely been selected to cope with infection of prevalent, plant-associated Gram-negative bacteria. Post-translational processing and modifications are substantially different for each of the four antibacterial peptides. While no similarities were observed among precursor structures of the various bee peptides, surprisingly, the signal sequences of abaecin (bee) and drosocin (Drosophila) shared unmistakable homology, possibly indicating common ancestral secretion/processing mechanisms. Finally, we report that bee defensin contains a typical structure (40 amino acids) but also a unique, amphipathic, putatively amidated carboxyl-terminal tail (10 amino acids). We speculate that this structure is a co-drug, assembled by fusing disulfide-rich and alpha-helical class peptide antibiotics, a novel concept in naturally occurring antibacterials." @default.
• W1517924874 created "2016-06-24" @default.
• W1517924874 creator A5009347072 @default.
• W1517924874 creator A5025261152 @default.
• W1517924874 creator A5048520859 @default.
• W1517924874 creator A5052495270 @default.
• W1517924874 creator A5054976422 @default.
• W1517924874 date "1994-11-01" @default.
• W1517924874 modified "2023-09-28" @default.
• W1517924874 title "Acute transcriptional response of the honeybee peptide-antibiotics gene repertoire and required post-translational conversion of the precursor structures." @default.
• W1517924874 cites W144997804 @default.
• W1517924874 cites W1515010604 @default.
• W1517924874 cites W1554703546 @default.
• W1517924874 cites W1563019217 @default.
• W1517924874 cites W1574787285 @default.
• W1517924874 cites W1574912127 @default.
• W1517924874 cites W1585060706 @default.
• W1517924874 cites W1587430592 @default.
• W1517924874 cites W1589725141 @default.
• W1517924874 cites W1648909091 @default.
• W1517924874 cites W1764864278 @default.
• W1517924874 cites W1975304761 @default.
• W1517924874 cites W197620025 @default.
• W1517924874 cites W1976415203 @default.
• W1517924874 cites W1980805742 @default.
• W1517924874 cites W1984408134 @default.
• W1517924874 cites W1995184275 @default.
• W1517924874 cites W1996359284 @default.
• W1517924874 cites W2011322938 @default.
• W1517924874 cites W2017922713 @default.
• W1517924874 cites W2018309785 @default.
• W1517924874 cites W2022236187 @default.
• W1517924874 cites W2032285333 @default.
• W1517924874 cites W2044132969 @default.
• W1517924874 cites W2053408544 @default.
• W1517924874 cites W2055437821 @default.
• W1517924874 cites W2063103311 @default.
• W1517924874 cites W2063324492 @default.
• W1517924874 cites W2066623432 @default.
• W1517924874 cites W2068620810 @default.
• W1517924874 cites W2073993982 @default.
• W1517924874 cites W2077358934 @default.
• W1517924874 cites W2080532845 @default.
• W1517924874 cites W2082542933 @default.
• W1517924874 cites W2088143384 @default.
• W1517924874 cites W2093730621 @default.
• W1517924874 cites W2095450147 @default.
• W1517924874 cites W2127175258 @default.
• W1517924874 cites W2138879032 @default.
• W1517924874 cites W2169150729 @default.
• W1517924874 cites W2292784247 @default.
• W1517924874 cites W310815860 @default.
• W1517924874 cites W38787200 @default.
• W1517924874 cites W4255020332 @default.
• W1517924874 doi "https://doi.org/10.1016/s0021-9258(19)61943-5" @default.
• W1517924874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7961803" @default.
• W1517924874 hasPublicationYear "1994" @default.
• W1517924874 type Work @default.
• W1517924874 sameAs 1517924874 @default.
• W1517924874 citedByCount "121" @default.
• W1517924874 countsByYear W15179248742012 @default.
• W1517924874 countsByYear W15179248742013 @default.
• W1517924874 countsByYear W15179248742014 @default.
• W1517924874 countsByYear W15179248742015 @default.
• W1517924874 countsByYear W15179248742016 @default.
• W1517924874 countsByYear W15179248742017 @default.
• W1517924874 countsByYear W15179248742018 @default.
• W1517924874 countsByYear W15179248742019 @default.
• W1517924874 countsByYear W15179248742020 @default.
• W1517924874 countsByYear W15179248742021 @default.
• W1517924874 countsByYear W15179248742022 @default.
• W1517924874 countsByYear W15179248742023 @default.
• W1517924874 crossrefType "journal-article" @default.
• W1517924874 hasAuthorship W1517924874A5009347072 @default.
• W1517924874 hasAuthorship W1517924874A5025261152 @default.
• W1517924874 hasAuthorship W1517924874A5048520859 @default.
• W1517924874 hasAuthorship W1517924874A5052495270 @default.
• W1517924874 hasAuthorship W1517924874A5054976422 @default.
• W1517924874 hasBestOaLocation W15179248741 @default.
• W1517924874 hasConcept C104317684 @default.
• W1517924874 hasConcept C121332964 @default.
• W1517924874 hasConcept C24890656 @default.
• W1517924874 hasConcept C2778473898 @default.
• W1517924874 hasConcept C2779281246 @default.
• W1517924874 hasConcept C501593827 @default.
• W1517924874 hasConcept C54355233 @default.
• W1517924874 hasConcept C55493867 @default.
• W1517924874 hasConcept C70721500 @default.
• W1517924874 hasConcept C86803240 @default.
• W1517924874 hasConcept C95444343 @default.
• W1517924874 hasConceptScore W1517924874C104317684 @default.
• W1517924874 hasConceptScore W1517924874C121332964 @default.
• W1517924874 hasConceptScore W1517924874C24890656 @default.
• W1517924874 hasConceptScore W1517924874C2778473898 @default.
• W1517924874 hasConceptScore W1517924874C2779281246 @default.
• W1517924874 hasConceptScore W1517924874C501593827 @default.
• W1517924874 hasConceptScore W1517924874C54355233 @default.
• W1517924874 hasConceptScore W1517924874C55493867 @default.

• next