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- W1518069543 abstract "ABSTRACT Glycation (Maillard reaction) starts from non‐enzymatic amino‐carbonyl reaction binding carbonyl group of reducing sugars to amino group of amino acids. The amino‐carbonyl reaction leads to the formation of the stable Amadori product, which ultimately forms advanced glycation end products (AGE). Acceleration of glycation during hyperglycemia increases the production and accumulation of AGE, which is implicated in the gradual development of diabetic complications in diabetes mellitus. Avian species offers the great advantage of providing animal models for diabetology because high blood glucose concentration should accelerate to generate high concentration of AGE. In the present study, radioactive AGE was prepared from chicken serum albumin and 14 C‐glucose. Radioactive AGE was administrated to examine the tissue distribution of AGE in chickens. Administration of radioactive AGE into the circulation of chickens revealed that AGE accumulated into specific tissues, liver, spleen and kidney, which have the function for clearing exogenous substances and endogenous metabolic waste products." @default.
- W1518069543 created "2016-06-24" @default.
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- W1518069543 date "2011-02-24" @default.
- W1518069543 modified "2023-10-17" @default.
- W1518069543 title "Tissue distribution of albumin-glucose advanced glycation end products administrated to chickens" @default.
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- W1518069543 doi "https://doi.org/10.1111/j.1740-0929.2010.00837.x" @default.
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