FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1518293453> ?p ?o ?g. }

• W1518293453 endingPage "6553" @default.
• W1518293453 startingPage "6545" @default.
• W1518293453 abstract "The mechanism of coupling of a cloned <i>Drosophila</i>D1-like dopamine receptor, DopR99B, to multiple second messenger systems when expressed in <i>Xenopus</i> oocytes is described. The receptor is coupled directly to the generation of a rapid, transient intracellular Ca²⁺ signal, monitored as changes in inward current mediated by the oocyte endogenous Ca²⁺-activated chloride channel, by a pertussis toxin-insensitive G-protein-coupled pathway. The more prolonged receptor-mediated changes in adenylyl cyclase activity are generated by an independent G-protein-coupled pathway that is pertussis toxin-sensitive but calcium-independent, and G_βγ-subunits appear to be involved in the transduction of this response. This is the first evidence for the direct coupling of a cloned D1-like dopamine receptor both to the activation of adenylyl cyclase and to the initiation of an intracellular Ca²⁺ signal. The pharmacological profile of both second messenger effects is identical for a range of naturally occurring catecholamine ligands (dopamine > norepinephrine > epinephrine) and for the blockade of dopamine responses by a range of synthetic antagonists. However, the pharmacological profiles of the two second messenger responses differ for a range of synthetic agonists. Thus, the receptor exhibits agonist-specific coupling to second messenger systems for synthetic agonists. This feature could provide a useful tool in the genetic analysis of the roles of the multiple second messenger pathways activated by this receptor, given the likely involvement of dopamine in the processes of learning and memory in the insect nervous system." @default.
• W1518293453 created "2016-06-24" @default.
• W1518293453 creator A5005121699 @default.
• W1518293453 creator A5018416759 @default.
• W1518293453 creator A5037579009 @default.
• W1518293453 creator A5083015130 @default.
• W1518293453 date "1997-09-01" @default.
• W1518293453 modified "2023-10-18" @default.
• W1518293453 title "Agonist-Specific Coupling of a ClonedDrosophila melanogasterD1-Like Dopamine Receptor to Multiple Second Messenger Pathways by Synthetic Agonists" @default.
• W1518293453 cites W1245933497 @default.
• W1518293453 cites W1514161613 @default.
• W1518293453 cites W1534263444 @default.
• W1518293453 cites W1552443285 @default.
• W1518293453 cites W1579285271 @default.
• W1518293453 cites W1605906079 @default.
• W1518293453 cites W1609084115 @default.
• W1518293453 cites W1957990440 @default.
• W1518293453 cites W1973715749 @default.
• W1518293453 cites W1978265572 @default.
• W1518293453 cites W1978410319 @default.
• W1518293453 cites W1979067492 @default.
• W1518293453 cites W1982449267 @default.
• W1518293453 cites W1990499518 @default.
• W1518293453 cites W1991650407 @default.
• W1518293453 cites W1997051338 @default.
• W1518293453 cites W2012905445 @default.
• W1518293453 cites W2021099775 @default.
• W1518293453 cites W2021614751 @default.
• W1518293453 cites W2023047245 @default.
• W1518293453 cites W2023699384 @default.
• W1518293453 cites W2024665801 @default.
• W1518293453 cites W2024669394 @default.
• W1518293453 cites W2026648332 @default.
• W1518293453 cites W2033836192 @default.
• W1518293453 cites W2037411216 @default.
• W1518293453 cites W2043001547 @default.
• W1518293453 cites W2063453694 @default.
• W1518293453 cites W2070925479 @default.
• W1518293453 cites W2072633855 @default.
• W1518293453 cites W2074390596 @default.
• W1518293453 cites W2079052515 @default.
• W1518293453 cites W2079625239 @default.
• W1518293453 cites W2081128554 @default.
• W1518293453 cites W2084176896 @default.
• W1518293453 cites W2087688448 @default.
• W1518293453 cites W2095222264 @default.
• W1518293453 cites W2097056699 @default.
• W1518293453 cites W2102541501 @default.
• W1518293453 cites W2112212749 @default.
• W1518293453 cites W2119851366 @default.
• W1518293453 cites W2145698708 @default.
• W1518293453 cites W2160146943 @default.
• W1518293453 cites W2165490898 @default.
• W1518293453 cites W2272491990 @default.
• W1518293453 cites W2327951898 @default.
• W1518293453 cites W2338218840 @default.
• W1518293453 cites W2346553109 @default.
• W1518293453 cites W2418973194 @default.
• W1518293453 cites W2419256972 @default.
• W1518293453 cites W2474503720 @default.
• W1518293453 doi "https://doi.org/10.1523/jneurosci.17-17-06545.1997" @default.
• W1518293453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6573129" @default.
• W1518293453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9254667" @default.
• W1518293453 hasPublicationYear "1997" @default.
• W1518293453 type Work @default.
• W1518293453 sameAs 1518293453 @default.
• W1518293453 citedByCount "83" @default.
• W1518293453 countsByYear W15182934532012 @default.
• W1518293453 countsByYear W15182934532013 @default.
• W1518293453 countsByYear W15182934532014 @default.
• W1518293453 countsByYear W15182934532015 @default.
• W1518293453 countsByYear W15182934532016 @default.
• W1518293453 countsByYear W15182934532017 @default.
• W1518293453 countsByYear W15182934532018 @default.
• W1518293453 countsByYear W15182934532019 @default.
• W1518293453 countsByYear W15182934532020 @default.
• W1518293453 countsByYear W15182934532021 @default.
• W1518293453 countsByYear W15182934532023 @default.
• W1518293453 crossrefType "journal-article" @default.
• W1518293453 hasAuthorship W1518293453A5005121699 @default.
• W1518293453 hasAuthorship W1518293453A5018416759 @default.
• W1518293453 hasAuthorship W1518293453A5037579009 @default.
• W1518293453 hasAuthorship W1518293453A5083015130 @default.
• W1518293453 hasBestOaLocation W15182934531 @default.
• W1518293453 hasConcept C120069818 @default.
• W1518293453 hasConcept C120750228 @default.
• W1518293453 hasConcept C134018914 @default.
• W1518293453 hasConcept C163235415 @default.
• W1518293453 hasConcept C170493617 @default.
• W1518293453 hasConcept C176303035 @default.
• W1518293453 hasConcept C185592680 @default.
• W1518293453 hasConcept C2778938600 @default.
• W1518293453 hasConcept C2779178603 @default.
• W1518293453 hasConcept C49773422 @default.
• W1518293453 hasConcept C513476851 @default.
• W1518293453 hasConcept C55493867 @default.
• W1518293453 hasConcept C62478195 @default.
• W1518293453 hasConcept C80631254 @default.

• next