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• W1518352584 abstract "This chapter reviews recent advances in understanding Aspergillus fumigatus-specific CD4+ T-cell activation and differentiation. Repeated exposure to fungal antigens is inconsequential in most individuals, due primarily to the rapid induction of antimicrobial defenses by innate immune cells of the airways. In some susceptible individuals, however, a variety of allergic responses to A. fumigatus, including allergic rhinitis, allergic sinusitis, and allergic asthma, can ensue. It has been documented that antigen presentation by pulmonary dendritic cells (DCs) primes Th2-biased CD4+ T-cell responses. One of the most studied mechanisms of pathogen recognition employed by DCs and other innate cells is through the family of Toll-like receptors (TLRs). Although studies of endogenous, polyclonal CD4+ T-cell responses to A. fumigatus have provided valuable information regarding the general kinetics of CD4+ T-cell activation and have demonstrated the contribution of CD4+ T cells in immunity to this fungal pathogen, they have not provided a full picture of CD4+ T-cell responses to A. fumigatus. Priming of CD4+ T cells by activated DCs presenting their cognate antigen results in vigorous T-cell proliferation and expansion of antigen-specific clones that can mediate protection against infection. Although the role of Th17 CD4+ T-cell responses in infection is just starting to be elucidated, it seems that Th17 CD4+ T-cell responses may be particularly important in immunity to fungi. The studies summarized in this chapter provide extensive experimental data demonstrating the participation of adaptive immune responses, in particular by CD4+ T lymphocytes, in antifungal immunity." @default.
• W1518352584 created "2016-06-24" @default.
• W1518352584 creator A5025998259 @default.
• W1518352584 creator A5029263589 @default.
• W1518352584 date "2014-04-09" @default.
• W1518352584 modified "2023-09-26" @default.
• W1518352584 title "CD4⁺T-Cell Responses to<i>Aspergillus fumigatus</i>" @default.
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