Matches in SemOpenAlex for { <https://semopenalex.org/work/W1518407873> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1518407873 endingPage "6225" @default.
- W1518407873 startingPage "6219" @default.
- W1518407873 abstract "The specific activity of alkaline phosphatase was increased in two human osteogenic sarcoma cell lines, SAOS and TE85, after treatment with 1,25 dihydroxy-vitamin D3 (1,25(OH)2D3). Enzyme activity increased when the cells were incubated with concentrations of 1,25(OH)2D3 between 10(-9) and 10(-7) M and cell growth was not inhibited at these concentrations. The specific activity of alkaline phosphatase was 4- to 7-fold higher than that in the control cells after 5 to 7 days of continuous exposure to 1,25(OH)2D3. Immunochemical studies demonstrated that the enzyme from both control and 1,25(OH)2D3-treated cultures cross-reacted with antisera specific for the phosphatase isoenzyme produced by normal human bone, and did not cross-react with antisera specific for the placental alkaline phosphatase isoenzyme. The increased enzyme activity in cultures induced with 1,25(OH)2D3 correlated with an absolute increase in the number of bone-specific phosphatase molecules, as determined by radioimmunoassay. No effect on alkaline phosphatase activity was observed when the cells were treated with other vitamin D metabolites or with 5-bromo-2'-deoxyuridine. Comparative studies demonstrated that hydrocortisone, another steroid hormone, increased the phosphatase activity with a different time course than did 1,25(OH)2D3. High affinity cytoplasmic receptors for 1,25(OH)2D3 and hydrocortisone were found in the SAOS and TE85 cells." @default.
- W1518407873 created "2016-06-24" @default.
- W1518407873 creator A5027634434 @default.
- W1518407873 creator A5050155837 @default.
- W1518407873 creator A5065668308 @default.
- W1518407873 creator A5082059757 @default.
- W1518407873 date "1983-05-01" @default.
- W1518407873 modified "2023-10-11" @default.
- W1518407873 title "1,25-Dihydroxyvitamin D3 increases bone alkaline phosphatase isoenzyme levels in human osteogenic sarcoma cells." @default.
- W1518407873 cites W1523493483 @default.
- W1518407873 cites W1527157268 @default.
- W1518407873 cites W1540384225 @default.
- W1518407873 cites W1553049056 @default.
- W1518407873 cites W1553453061 @default.
- W1518407873 cites W1775749144 @default.
- W1518407873 cites W1900009484 @default.
- W1518407873 cites W1966674933 @default.
- W1518407873 cites W1983649348 @default.
- W1518407873 cites W1989744185 @default.
- W1518407873 cites W1994013086 @default.
- W1518407873 cites W1995731868 @default.
- W1518407873 cites W1999156064 @default.
- W1518407873 cites W2024632937 @default.
- W1518407873 cites W2032611154 @default.
- W1518407873 cites W2036088433 @default.
- W1518407873 cites W2050951459 @default.
- W1518407873 cites W2063637394 @default.
- W1518407873 cites W2066419852 @default.
- W1518407873 cites W2070704589 @default.
- W1518407873 cites W2082198146 @default.
- W1518407873 cites W2087265330 @default.
- W1518407873 cites W2091814173 @default.
- W1518407873 cites W2091988211 @default.
- W1518407873 cites W2155510455 @default.
- W1518407873 cites W2167132436 @default.
- W1518407873 cites W2180538641 @default.
- W1518407873 doi "https://doi.org/10.1016/s0021-9258(18)32395-0" @default.
- W1518407873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6189822" @default.
- W1518407873 hasPublicationYear "1983" @default.
- W1518407873 type Work @default.
- W1518407873 sameAs 1518407873 @default.
- W1518407873 citedByCount "81" @default.
- W1518407873 countsByYear W15184078732013 @default.
- W1518407873 countsByYear W15184078732022 @default.
- W1518407873 crossrefType "journal-article" @default.
- W1518407873 hasAuthorship W1518407873A5027634434 @default.
- W1518407873 hasAuthorship W1518407873A5050155837 @default.
- W1518407873 hasAuthorship W1518407873A5065668308 @default.
- W1518407873 hasAuthorship W1518407873A5082059757 @default.
- W1518407873 hasBestOaLocation W15184078731 @default.
- W1518407873 hasConcept C119795356 @default.
- W1518407873 hasConcept C126322002 @default.
- W1518407873 hasConcept C134018914 @default.
- W1518407873 hasConcept C142724271 @default.
- W1518407873 hasConcept C160160445 @default.
- W1518407873 hasConcept C181199279 @default.
- W1518407873 hasConcept C185592680 @default.
- W1518407873 hasConcept C2777760704 @default.
- W1518407873 hasConcept C2778256501 @default.
- W1518407873 hasConcept C502942594 @default.
- W1518407873 hasConcept C55493867 @default.
- W1518407873 hasConcept C71924100 @default.
- W1518407873 hasConcept C86803240 @default.
- W1518407873 hasConceptScore W1518407873C119795356 @default.
- W1518407873 hasConceptScore W1518407873C126322002 @default.
- W1518407873 hasConceptScore W1518407873C134018914 @default.
- W1518407873 hasConceptScore W1518407873C142724271 @default.
- W1518407873 hasConceptScore W1518407873C160160445 @default.
- W1518407873 hasConceptScore W1518407873C181199279 @default.
- W1518407873 hasConceptScore W1518407873C185592680 @default.
- W1518407873 hasConceptScore W1518407873C2777760704 @default.
- W1518407873 hasConceptScore W1518407873C2778256501 @default.
- W1518407873 hasConceptScore W1518407873C502942594 @default.
- W1518407873 hasConceptScore W1518407873C55493867 @default.
- W1518407873 hasConceptScore W1518407873C71924100 @default.
- W1518407873 hasConceptScore W1518407873C86803240 @default.
- W1518407873 hasIssue "10" @default.
- W1518407873 hasLocation W15184078731 @default.
- W1518407873 hasOpenAccess W1518407873 @default.
- W1518407873 hasPrimaryLocation W15184078731 @default.
- W1518407873 hasRelatedWork W1630209420 @default.
- W1518407873 hasRelatedWork W2034500436 @default.
- W1518407873 hasRelatedWork W2084052244 @default.
- W1518407873 hasRelatedWork W2199922158 @default.
- W1518407873 hasRelatedWork W2320346276 @default.
- W1518407873 hasRelatedWork W2431198747 @default.
- W1518407873 hasRelatedWork W2950308704 @default.
- W1518407873 hasRelatedWork W3122727118 @default.
- W1518407873 hasRelatedWork W4242995846 @default.
- W1518407873 hasRelatedWork W4292236581 @default.
- W1518407873 hasVolume "258" @default.
- W1518407873 isParatext "false" @default.
- W1518407873 isRetracted "false" @default.
- W1518407873 magId "1518407873" @default.
- W1518407873 workType "article" @default.