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- W1518706191 abstract "The association between protective immunity, delayed hypersensitivity (DTH) and in vitro antigen specific lymphocyte transformation (ASLT) has been studied during the course of BCG infection in mice. The peak ASLT response was obtained 2 weeks after a subcutaneous footpad infection using lymph node cells draining the immunization site. This response decreased to a low but statistically significant level by week 4 and persisted indefinitely thereafter. A similar course of events was observed in splenic cell cultures, but the size of the response was smaller. The reactive cells were shown to be T-lymphocytes. The ability to express DTH to tuberculin purified protein derivative coincided with the emergence of cells capable of responding in ASLT assays. In contrast, there was a poor association between ASLT and protective immunity: lymphocytes from lymph nodes that did not drain the immunization site conferred substantial protective immunity but nonetheless failed to respond significantly in ASLT assays. The latter failure could not be attributed to insufficiency of sensitized lymphocytes and was independent of the antigen concentration and the culture incubation time. It was concluded that the ASLT reactive cells were either immunoblasts or recent progeny of these cells." @default.
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- W1518706191 date "1978-05-01" @default.
- W1518706191 modified "2023-09-25" @default.
- W1518706191 title "Antigen specific lymphocyte transformation, delayed hypersensitivity and protective immunity" @default.
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- W1518706191 doi "https://doi.org/10.1016/0008-8749(78)90200-9" @default.
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