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- W1518761532 endingPage "1583" @default.
- W1518761532 startingPage "1574" @default.
- W1518761532 abstract "Prenatal development is highly sensitive to maternal drug use due to the vulnerability for disruption of the fetal brain with its ongoing neurodevelopment, resulting in lifelong consequences that can enhance risk for psychiatric disorders. Cannabis and cigarettes are the most commonly used illicit and licit substances, respectively, among pregnant women. Although the behavioral consequences of prenatal cannabis and cigarette exposure have been well-documented in epidemiological and clinical studies, only recently have investigations into the molecular mechanisms associated with the developmental impact of early drug exposure been addressed. This article reviews the literature relevant to long-term gene expression disturbances in the human fetal brain in relation to maternal cannabis and cigarette use. To provide translational insights, we discuss animal models in which protracted molecular consequences of prenatal cannabis and cigarette exposure can be better explored and which enable future evaluation of epigenetic pathways, such as DNA methylation and histone modification, that could potentially maintain abnormal gene regulation and related behavioral disturbances. Altogether, this information may help to address the current gaps of knowledge regarding the impact of early drug exposure that set in motion lifelong molecular disturbances that underlie vulnerability to psychiatric disorders." @default.
- W1518761532 created "2016-06-24" @default.
- W1518761532 creator A5008948310 @default.
- W1518761532 creator A5044396164 @default.
- W1518761532 creator A5055662688 @default.
- W1518761532 creator A5083825817 @default.
- W1518761532 date "2011-11-01" @default.
- W1518761532 modified "2023-10-14" @default.
- W1518761532 title "Molecular mechanisms of maternal cannabis and cigarette use on human neurodevelopment" @default.
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