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• W1518823821 abstract "In three experiments, involving a total of seventy-six rats, the effects of varying levels of dietary calcium, dietary phosphorus remaining constant, and of dietary phosphorus, dietary calcium remaining constant, and of dietary phosphorus, dietary calcium remaining constant, on the retention and distribution of low levels of dietary fluorine (9, 12 and 32 p.p.m.) among skeleton, teeth and soft tissues were determined. The experiments involved equalized feeding of rats on comparable rations, analysis of check rats at the start of the experiments and analysis of all experimental rats at the termination of feeding periods during which 1000 gm., 500 gm., and 600 gm. of food were consumed, respectively, per rat. The results secured warrant the following conclusions: An increase in the concentration of dietary calcium from 0.23 to 0.73%, phosphorus remaining constant, produces a distinctly heavier dry fat-free skeleton, containing significantly higher percentages of ash, calcium and phosphorus in the growing rat. On the other hand, it depresses the total retention of fluorine by 10 to 13%, and to a greater extent the deposition of fluorine in teeth and soft tissue. Quite probably this protective action of calcium against assimilation of fluorine is greater in young than in older rats. An increase in the concentration of dietary phosphorus from 0.14 to 0.71%, dietary calcium remaining constant, produces in young growing rats a greater appetite for food, a slightly greater rate of growth and a distinctly heavier dry fat-free skeleton. However, it does not modify appreciably the total retention of fluorine or the distribution of retained fluorine among bones, teeth and soft tissue. The increased weight of skeleton with no increase in its content of fluorine, does, however, depress the concentration of fluorine in the dry fat-free bones. Presumably dietary calcium consumed in concentrations above certain minimum (inadequate ?) levels, protects the body against dietary fluorine, in food or in water, by impairing its assimilation to some extent, especially in those tissues, the teeth and the soft tissues, where its most deleterious effects would be exerted." @default.
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• W1518823821 date "1941-07-01" @default.
• W1518823821 modified "2023-10-16" @default.
• W1518823821 title "The Effect of Dietary Calcium and Phosphorus on the Assimilation of Dietary Fluorine" @default.
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• W1518823821 doi "https://doi.org/10.1093/jn/22.1.91" @default.
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