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- W1518981777 abstract "Intraperitoneal injections in rats of 8 mg 6-methylpurine/kg of body weight led to constantly increasing elevations in the plasma phosphohexose isomerase and lactic dehydrogenase activities. Nineteen days after the injection, the isomerase and dehydrogenase activities had risen to about 8-fold and 3-fold the control values, respectively.These plasma enzyme elevations were accompanied by substantial and significant decreases of the enzyme activities in the liver, but by minor and generally insignificant decreases in skeletal muscle and erythrocytes. The 6-methylpurine-injected rats showed losses in body and liver weight, but rats starved to points of corresponding or greater loss of weight exhibited only minor and generally insignificant increases in plasma enzyme and decreases in liver enzyme activities.The absence of any consistent histologic abnormalities in the livers of the 6-methylpurine-injected rats indicated that alterations in the cell other than those leading to cell necrosis accounted for the release of enzyme proteins into the circulation." @default.
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- W1518981777 date "1958-07-01" @default.
- W1518981777 modified "2023-09-26" @default.
- W1518981777 title "Effect of 6-methylpurine on phosphohexose isomerase and lactic dehydrogenase activities of plasma, erythrocytes, liver, and skeletal muscle." @default.
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