Matches in SemOpenAlex for { <https://semopenalex.org/work/W1519030095> ?p ?o ?g. }
- W1519030095 endingPage "199" @default.
- W1519030095 startingPage "181" @default.
- W1519030095 abstract "The HO-1 isoenzyme is an early stress response gene regulated by many forms of oxidative stress. The HO-2 isoenzyme is predominantly a constitutive enzyme, which may serve to sequester heme as well as degrade it. All HO enzyme activity results in the degradation of heme and the production of antioxidant bile pigments, which would favor an antioxidant role for the enzyme. In fact, in oxidative stress in vitro, HO-1 is protective (91-94) but within a narrow threshold of overexpression (93,94) in some models, since iron released in the HO reaction may obviate any cytoprotective effect (Fig. 3). So far, HO-2 appears to be beneficial in oxygen toxicity in vivo, but the consequences of HO-2 overexpression have not yet been tested. It will be important to better define the role of each HO isoenzyme in oxidative stress so as to determine whether enhancing these complex systems could alleviate some of the cellular changes seen as a result of oxidative injury. Furthermore, prior to considering therapeutic maneuvers to enhance HO, a complete understanding of the physiologic consequences of HO-1 induction and associated reactions, in each particular setting, will be crucial." @default.
- W1519030095 created "2016-06-24" @default.
- W1519030095 creator A5083304330 @default.
- W1519030095 date "2001-01-01" @default.
- W1519030095 modified "2023-09-24" @default.
- W1519030095 title "Regulation and role of heme oxygenase in oxidative injury" @default.
- W1519030095 cites W1496912643 @default.
- W1519030095 cites W1497069076 @default.
- W1519030095 cites W1501532586 @default.
- W1519030095 cites W1521258655 @default.
- W1519030095 cites W1523795452 @default.
- W1519030095 cites W1529716765 @default.
- W1519030095 cites W1583403542 @default.
- W1519030095 cites W1589066506 @default.
- W1519030095 cites W1592548488 @default.
- W1519030095 cites W1621595817 @default.
- W1519030095 cites W1897823322 @default.
- W1519030095 cites W1963676888 @default.
- W1519030095 cites W1965191768 @default.
- W1519030095 cites W1966557915 @default.
- W1519030095 cites W1966582616 @default.
- W1519030095 cites W1966973099 @default.
- W1519030095 cites W1969808150 @default.
- W1519030095 cites W1970121396 @default.
- W1519030095 cites W1973081785 @default.
- W1519030095 cites W1973593141 @default.
- W1519030095 cites W1974371318 @default.
- W1519030095 cites W1976127826 @default.
- W1519030095 cites W1977667808 @default.
- W1519030095 cites W1978719611 @default.
- W1519030095 cites W1979672764 @default.
- W1519030095 cites W1981914908 @default.
- W1519030095 cites W1982669384 @default.
- W1519030095 cites W1984318419 @default.
- W1519030095 cites W1985863048 @default.
- W1519030095 cites W1993596487 @default.
- W1519030095 cites W1994399330 @default.
- W1519030095 cites W1995016231 @default.
- W1519030095 cites W1995726976 @default.
- W1519030095 cites W1997665579 @default.
- W1519030095 cites W2001017372 @default.
- W1519030095 cites W2013790946 @default.
- W1519030095 cites W2019200361 @default.
- W1519030095 cites W2019934265 @default.
- W1519030095 cites W2020170334 @default.
- W1519030095 cites W2022560636 @default.
- W1519030095 cites W2025723657 @default.
- W1519030095 cites W2029237695 @default.
- W1519030095 cites W2030117230 @default.
- W1519030095 cites W2030383132 @default.
- W1519030095 cites W2031923131 @default.
- W1519030095 cites W2032408328 @default.
- W1519030095 cites W2032731524 @default.
- W1519030095 cites W2033914311 @default.
- W1519030095 cites W2035776773 @default.
- W1519030095 cites W2037190368 @default.
- W1519030095 cites W2039091843 @default.
- W1519030095 cites W2040118144 @default.
- W1519030095 cites W2040802054 @default.
- W1519030095 cites W2041553103 @default.
- W1519030095 cites W2050580817 @default.
- W1519030095 cites W2053322737 @default.
- W1519030095 cites W2054924599 @default.
- W1519030095 cites W2055655700 @default.
- W1519030095 cites W2056210468 @default.
- W1519030095 cites W2056905161 @default.
- W1519030095 cites W2061778017 @default.
- W1519030095 cites W2067040292 @default.
- W1519030095 cites W2067199421 @default.
- W1519030095 cites W2067714284 @default.
- W1519030095 cites W2074253297 @default.
- W1519030095 cites W2074598619 @default.
- W1519030095 cites W2074733139 @default.
- W1519030095 cites W2076014304 @default.
- W1519030095 cites W2081098997 @default.
- W1519030095 cites W2081635255 @default.
- W1519030095 cites W2094764360 @default.
- W1519030095 cites W2097498628 @default.
- W1519030095 cites W2114135209 @default.
- W1519030095 cites W2124433916 @default.
- W1519030095 cites W2124595022 @default.
- W1519030095 cites W2127223050 @default.
- W1519030095 cites W2130066440 @default.
- W1519030095 cites W2139309437 @default.
- W1519030095 cites W2205010277 @default.
- W1519030095 cites W2272766961 @default.
- W1519030095 cites W2312297578 @default.
- W1519030095 cites W2341956512 @default.
- W1519030095 cites W2412567408 @default.
- W1519030095 cites W2437544824 @default.
- W1519030095 cites W32952758 @default.
- W1519030095 cites W1965926880 @default.
- W1519030095 doi "https://doi.org/10.1016/s0070-2137(01)80008-x" @default.
- W1519030095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10842752" @default.
- W1519030095 hasPublicationYear "2001" @default.
- W1519030095 type Work @default.
- W1519030095 sameAs 1519030095 @default.
- W1519030095 citedByCount "143" @default.