FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1519152316> ?p ?o ?g. }

• W1519152316 endingPage "10977" @default.
• W1519152316 startingPage "10971" @default.
• W1519152316 abstract "The capacity of epinephrine alone and the combination of low dose epinephrine and ADP to support the binding of fibrinogen to washed human platelets has been examined, 125I-Fibrinogen was bound to epinephrine-stimulated platelets, but 90 min were required to achieve maximal binding at 22 degrees C in contrast to 20 to 30 min with ADP. The overall rate of interaction appeared to reflect the slow binding of fibrinogen to epinephrine-stimulated platelets as opposed to the rate of stimulation of the cell. Divalent ions were required for binding of fibrinogen to epinephrine-stimulated platelets, and both calcium and magnesium supported binding with a prolonged time course. Fibrinogen binding was maximally supported by 20 to 30 microM epinephrine. The combination of low dose epinephrine (5 microM) and low dose ADP (0.5 microM), which acted synergistically to induce platelet aggregation, supported the rapid (10 min) binding of fibrinogen to platelets. With 4 microM epinephrine, more fibrinogen bound per platelet at all ADP doses than with ADP alone. With all the stimuli, saturable binding of fibrinogen to the platelet was observed, and Scatchard plots were linear, yielding very similar apparent association constants. The number of molecules bound per cell was stimulus-dependent, with 30 microM epinephrine inducing the binding of fewer fibrinogen molecules per cell (mean = 20,400) than 10 microM ADP (mean = 35,900) or the combination of 5 microM epinephrine + 0.5 microM ADP (mean = 43,600). The participation of endogenous ADP in fibrinogen binding to epinephrine-stimulated platelets was suggested since enzymes which remove ADP, apyrase, and creatine phosphate/creatine phosphokinase, and the ADP analogue, 2-chloroadenosine, completely inhibited the binding of fibrinogen to the platelet." @default.
• W1519152316 created "2016-06-24" @default.
• W1519152316 creator A5042974889 @default.
• W1519152316 creator A5059303510 @default.
• W1519152316 date "1980-11-01" @default.
• W1519152316 modified "2023-10-18" @default.
• W1519152316 title "Induction of the fibrinogen receptor on human platelets by epinephrine and the combination of epinephrine and ADP." @default.
• W1519152316 cites W1205893196 @default.
• W1519152316 cites W1234014522 @default.
• W1519152316 cites W1512771871 @default.
• W1519152316 cites W1529471367 @default.
• W1519152316 cites W1545341742 @default.
• W1519152316 cites W1970649123 @default.
• W1519152316 cites W1976666984 @default.
• W1519152316 cites W1982830554 @default.
• W1519152316 cites W1990942696 @default.
• W1519152316 cites W1998136748 @default.
• W1519152316 cites W2002671469 @default.
• W1519152316 cites W2009967151 @default.
• W1519152316 cites W2025809800 @default.
• W1519152316 cites W2027589205 @default.
• W1519152316 cites W2028639923 @default.
• W1519152316 cites W202976643 @default.
• W1519152316 cites W2035423234 @default.
• W1519152316 cites W2056798741 @default.
• W1519152316 cites W2067335440 @default.
• W1519152316 cites W2089000657 @default.
• W1519152316 cites W2166359876 @default.
• W1519152316 cites W2235072774 @default.
• W1519152316 cites W2316091952 @default.
• W1519152316 cites W4239882846 @default.
• W1519152316 doi "https://doi.org/10.1016/s0021-9258(19)70402-5" @default.
• W1519152316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6253495" @default.
• W1519152316 hasPublicationYear "1980" @default.
• W1519152316 type Work @default.
• W1519152316 sameAs 1519152316 @default.
• W1519152316 citedByCount "99" @default.
• W1519152316 countsByYear W15191523162016 @default.
• W1519152316 countsByYear W15191523162018 @default.
• W1519152316 countsByYear W15191523162019 @default.
• W1519152316 crossrefType "journal-article" @default.
• W1519152316 hasAuthorship W1519152316A5042974889 @default.
• W1519152316 hasAuthorship W1519152316A5059303510 @default.
• W1519152316 hasBestOaLocation W15191523161 @default.
• W1519152316 hasConcept C126322002 @default.
• W1519152316 hasConcept C134018914 @default.
• W1519152316 hasConcept C170493617 @default.
• W1519152316 hasConcept C185592680 @default.
• W1519152316 hasConcept C2775859304 @default.
• W1519152316 hasConcept C2779036427 @default.
• W1519152316 hasConcept C71924100 @default.
• W1519152316 hasConcept C89560881 @default.
• W1519152316 hasConcept C98274493 @default.
• W1519152316 hasConceptScore W1519152316C126322002 @default.
• W1519152316 hasConceptScore W1519152316C134018914 @default.
• W1519152316 hasConceptScore W1519152316C170493617 @default.
• W1519152316 hasConceptScore W1519152316C185592680 @default.
• W1519152316 hasConceptScore W1519152316C2775859304 @default.
• W1519152316 hasConceptScore W1519152316C2779036427 @default.
• W1519152316 hasConceptScore W1519152316C71924100 @default.
• W1519152316 hasConceptScore W1519152316C89560881 @default.
• W1519152316 hasConceptScore W1519152316C98274493 @default.
• W1519152316 hasIssue "22" @default.
• W1519152316 hasLocation W15191523161 @default.
• W1519152316 hasOpenAccess W1519152316 @default.
• W1519152316 hasPrimaryLocation W15191523161 @default.
• W1519152316 hasRelatedWork W1490975006 @default.
• W1519152316 hasRelatedWork W1965032919 @default.
• W1519152316 hasRelatedWork W2002786746 @default.
• W1519152316 hasRelatedWork W2003348660 @default.
• W1519152316 hasRelatedWork W2037107047 @default.
• W1519152316 hasRelatedWork W2378801674 @default.
• W1519152316 hasRelatedWork W2406642749 @default.
• W1519152316 hasRelatedWork W2408985580 @default.
• W1519152316 hasRelatedWork W2414389701 @default.
• W1519152316 hasRelatedWork W2414762872 @default.
• W1519152316 hasVolume "255" @default.
• W1519152316 isParatext "false" @default.
• W1519152316 isRetracted "false" @default.
• W1519152316 magId "1519152316" @default.
• W1519152316 workType "article" @default.