FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1519210048> ?p ?o ?g. }

• W1519210048 endingPage "257" @default.
• W1519210048 startingPage "247" @default.
• W1519210048 abstract "The precise mechanisms of antioxidant-mediated longevity are poorly understood. We show that an antioxidant treatment can extend the lifespan of Caenorhabditis elegans (C. elegans) through the nuclear translocation of the forkhead box O transcription factor (FoxO) homolog DAF-16. This pathway was found to involve 3-phosphoinositide-dependent kinase-1 (PDK-1) and serum- and glucocorticoid-regulated kinase-1 (SGK-1), distinct from the known oxidative stress-mediated mechanism in which FoxO3a translocation is regulated by c-Jun N-terminal kinase (JNK) and mammalian sterile 20-like kinase-1 (MST-1). The differences in the mechanisms of FoxO activation by antioxidants and oxidants result in differences in FoxO phosphorylation and target gene expression. Based on these results, we found that a combination of early antioxidant treatment and late oxidant treatment is most effective for lifespan extension in C. elegans. © 2013 BioFactors, 40(2):247–257, 2014" @default.
• W1519210048 created "2016-06-24" @default.
• W1519210048 creator A5064143592 @default.
• W1519210048 creator A5072667589 @default.
• W1519210048 creator A5082013860 @default.
• W1519210048 date "2013-09-30" @default.
• W1519210048 modified "2023-10-18" @default.
• W1519210048 title "A DAF-16/FoxO3a-dependent longevity signal is initiated by antioxidants" @default.
• W1519210048 cites W1486595217 @default.
• W1519210048 cites W1968734141 @default.
• W1519210048 cites W1981614332 @default.
• W1519210048 cites W1982433564 @default.
• W1519210048 cites W1983633928 @default.
• W1519210048 cites W1986559713 @default.
• W1519210048 cites W1989323843 @default.
• W1519210048 cites W1991080848 @default.
• W1519210048 cites W1992454850 @default.
• W1519210048 cites W1995008569 @default.
• W1519210048 cites W1996181447 @default.
• W1519210048 cites W2004129180 @default.
• W1519210048 cites W2005029264 @default.
• W1519210048 cites W2007530728 @default.
• W1519210048 cites W2012161830 @default.
• W1519210048 cites W2016555970 @default.
• W1519210048 cites W2016730049 @default.
• W1519210048 cites W2032208441 @default.
• W1519210048 cites W2033261332 @default.
• W1519210048 cites W2037536506 @default.
• W1519210048 cites W2037813091 @default.
• W1519210048 cites W2043287965 @default.
• W1519210048 cites W2043495443 @default.
• W1519210048 cites W2043829280 @default.
• W1519210048 cites W2043966795 @default.
• W1519210048 cites W2055298543 @default.
• W1519210048 cites W2065652048 @default.
• W1519210048 cites W2074783650 @default.
• W1519210048 cites W2076943958 @default.
• W1519210048 cites W2079797384 @default.
• W1519210048 cites W2080763394 @default.
• W1519210048 cites W2083439334 @default.
• W1519210048 cites W2083718982 @default.
• W1519210048 cites W2084982074 @default.
• W1519210048 cites W2095422645 @default.
• W1519210048 cites W2101861123 @default.
• W1519210048 cites W2113002082 @default.
• W1519210048 cites W2114570899 @default.
• W1519210048 cites W2123887536 @default.
• W1519210048 cites W2125927829 @default.
• W1519210048 cites W2137035181 @default.
• W1519210048 cites W2144005841 @default.
• W1519210048 cites W2146533779 @default.
• W1519210048 cites W2166146113 @default.
• W1519210048 cites W2169494292 @default.
• W1519210048 cites W2170363318 @default.
• W1519210048 cites W2315512556 @default.
• W1519210048 cites W4231442978 @default.
• W1519210048 doi "https://doi.org/10.1002/biof.1146" @default.
• W1519210048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24123695" @default.
• W1519210048 hasPublicationYear "2013" @default.
• W1519210048 type Work @default.
• W1519210048 sameAs 1519210048 @default.
• W1519210048 citedByCount "23" @default.
• W1519210048 countsByYear W15192100482015 @default.
• W1519210048 countsByYear W15192100482016 @default.
• W1519210048 countsByYear W15192100482017 @default.
• W1519210048 countsByYear W15192100482018 @default.
• W1519210048 countsByYear W15192100482019 @default.
• W1519210048 countsByYear W15192100482020 @default.
• W1519210048 countsByYear W15192100482021 @default.
• W1519210048 countsByYear W15192100482022 @default.
• W1519210048 countsByYear W15192100482023 @default.
• W1519210048 crossrefType "journal-article" @default.
• W1519210048 hasAuthorship W1519210048A5064143592 @default.
• W1519210048 hasAuthorship W1519210048A5072667589 @default.
• W1519210048 hasAuthorship W1519210048A5082013860 @default.
• W1519210048 hasConcept C104317684 @default.
• W1519210048 hasConcept C138626823 @default.
• W1519210048 hasConcept C184235292 @default.
• W1519210048 hasConcept C185592680 @default.
• W1519210048 hasConcept C2776151105 @default.
• W1519210048 hasConcept C2776529522 @default.
• W1519210048 hasConcept C2776759703 @default.
• W1519210048 hasConcept C2778004101 @default.
• W1519210048 hasConcept C2778944004 @default.
• W1519210048 hasConcept C54355233 @default.
• W1519210048 hasConcept C55493867 @default.
• W1519210048 hasConcept C62478195 @default.
• W1519210048 hasConcept C86339819 @default.
• W1519210048 hasConcept C86803240 @default.
• W1519210048 hasConcept C95444343 @default.
• W1519210048 hasConcept C97029542 @default.
• W1519210048 hasConceptScore W1519210048C104317684 @default.
• W1519210048 hasConceptScore W1519210048C138626823 @default.
• W1519210048 hasConceptScore W1519210048C184235292 @default.
• W1519210048 hasConceptScore W1519210048C185592680 @default.
• W1519210048 hasConceptScore W1519210048C2776151105 @default.
• W1519210048 hasConceptScore W1519210048C2776529522 @default.
• W1519210048 hasConceptScore W1519210048C2776759703 @default.

• next