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- W1519210068 abstract "The production of α, β and γ interferons (IFN) and interleukin 2 (IL-2) by Lyt-2+-dependent cytotoxic T-cell lines/clones was investigated. Cloned and uncloned T-cell lines specific for H-2Dd or the unique RL♂1 leukemia antigen were studied. After infection with Sendai virus (SV) or Newcastle disease virus (NDV) all cell lines produced IFN-α and -β. Induction of IFN-γ was attempted with the mitogens Con A, PHA, PWM, SEA, and SEB, with poly(I:C), with antibodies Lyt-1.2, -2.2, and Thy-1.2, or with the target cells Meth A (H-2Dd+) and RL♂1. All mitogens were effective inducers. However, the antibodies and poly(I:C) were not. One uncloned RL♂1-specific cell line CTLL-RP, produced IFN-γ after induction with RL♂1. Production of IFN-α, β depended on IL-2, whereas production of IFN-γ did not, although addition of highly purified IL-2 increased IFN-γ production even in the absence of other inducers. Crude IL-2 inhibited the production of IFN-γ but not IFN-α, β. In response to mitogens, some T-cell clones also produced IL-2. The results demonstrate that Lyt-2+ cells can produce a broad spectrum of lymphokine activities after appropriate stimulation. Their availability now affords us the opportunity to study the regulation of lymphokine production at the clonal level." @default.
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- W1519210068 date "1983-10-01" @default.
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- W1519210068 title "Characterization of interleukin 2-dependent cytotoxic T-cell clones" @default.
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- W1519210068 doi "https://doi.org/10.1016/0008-8749(83)90239-3" @default.
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