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- W1519228434 endingPage "1361" @default.
- W1519228434 startingPage "1351" @default.
- W1519228434 abstract "The canonical Wnt signaling pathway has been the focus of intensive research because of its frequent dysregulation in human cancers. Much of this has been directed towards the aberrant expression and/or activity of the central mediator of this pathway, β-catenin. In particular, the nuclear localization of β-catenin and subsequent inappropriate activation of TCF/LEF-mediated transcription appears to be an important process in both the establishment and maintenance of cancer stem cells. Despite this, the exact mechanisms controlling β-catenin nuclear localization in both normal and malignant cells are poorly understood. This prospect article brings together the many mechanisms previously reported to regulate the nuclear localization of β-catenin and how they are relevant to cancer." @default.
- W1519228434 created "2016-06-24" @default.
- W1519228434 creator A5010617221 @default.
- W1519228434 creator A5019283964 @default.
- W1519228434 creator A5032482657 @default.
- W1519228434 creator A5084922039 @default.
- W1519228434 date "2014-06-17" @default.
- W1519228434 modified "2023-10-05" @default.
- W1519228434 title "Factors Affecting the Nuclear Localization of β-Catenin in Normal and Malignant Tissue" @default.
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