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- W1519237973 startingPage "406" @default.
- W1519237973 abstract "IL-17-producing Th17 cells are of critical importance in host defense against oropharyngeal candidiasis (OPC). Speculation about defective Th17 responses to oral C. albicans infection in the context of HIV infection prompted an investigation of innate and adaptive immune responses to Candida albicans in transgenic mice expressing the genome of HIV-1 in immune cells and displaying an AIDS-like disease. Defective IL-17 and IL-22-dependent mucosal responses to C. albicans were found to determine susceptibility to OPC in these transgenic mice. Innate phagocytes were quantitatively and functionally intact, and individually dispensable for control of OPC and to prevent systemic dissemination of Candida to deep organs. CD8+ T-cells recruited to the oral mucosa of the transgenic mice limited the proliferation of C. albicans in these conditions of CD4+ T-cell deficiency. Therefore, the immunopathogenesis of OPC in the context of HIV infection involves defective T-cell-mediated immunity, failure of crosstalk with innate mucosal immune effector mechanisms, and compensatory cell responses, which limit Candida infection to the oral mucosa and prevent systemic dissemination." @default.
- W1519237973 created "2016-06-24" @default.
- W1519237973 creator A5060855573 @default.
- W1519237973 creator A5066649593 @default.
- W1519237973 creator A5082333058 @default.
- W1519237973 date "2015-06-23" @default.
- W1519237973 modified "2023-10-02" @default.
- W1519237973 title "Oropharyngeal Candidiasis in HIV Infection: Analysis of Impaired Mucosal Immune Response to Candida albicans in Mice Expressing the HIV-1 Transgene" @default.
- W1519237973 cites W1486266992 @default.
- W1519237973 cites W1500518582 @default.
- W1519237973 cites W1588732320 @default.
- W1519237973 cites W1601934305 @default.
- W1519237973 cites W1620097935 @default.
- W1519237973 cites W1809324973 @default.
- W1519237973 cites W1892811633 @default.
- W1519237973 cites W1914430557 @default.
- W1519237973 cites W1923814307 @default.
- W1519237973 cites W1942668068 @default.
- W1519237973 cites W1964077677 @default.
- W1519237973 cites W1968178710 @default.
- W1519237973 cites W1968310230 @default.
- W1519237973 cites W1968661266 @default.
- W1519237973 cites W1970025115 @default.
- W1519237973 cites W1970612403 @default.
- W1519237973 cites W1972960900 @default.
- W1519237973 cites W1978566978 @default.
- W1519237973 cites W1980690767 @default.
- W1519237973 cites W1981032637 @default.
- W1519237973 cites W1982506988 @default.
- W1519237973 cites W1983091225 @default.
- W1519237973 cites W1993894494 @default.
- W1519237973 cites W1995529275 @default.
- W1519237973 cites W1996005331 @default.
- W1519237973 cites W1998472383 @default.
- W1519237973 cites W1998541797 @default.
- W1519237973 cites W2002134574 @default.
- W1519237973 cites W2002987322 @default.
- W1519237973 cites W2004650652 @default.
- W1519237973 cites W2007121925 @default.
- W1519237973 cites W2016488838 @default.
- W1519237973 cites W2016723478 @default.
- W1519237973 cites W2021381458 @default.
- W1519237973 cites W2021894986 @default.
- W1519237973 cites W2022114264 @default.
- W1519237973 cites W2024362866 @default.
- W1519237973 cites W2025084949 @default.
- W1519237973 cites W2027890910 @default.
- W1519237973 cites W2034453891 @default.
- W1519237973 cites W2034582472 @default.
- W1519237973 cites W2036619734 @default.
- W1519237973 cites W2038020214 @default.
- W1519237973 cites W2038683721 @default.
- W1519237973 cites W2040537700 @default.
- W1519237973 cites W2041046681 @default.
- W1519237973 cites W2042645524 @default.
- W1519237973 cites W2043520974 @default.
- W1519237973 cites W2043739848 @default.
- W1519237973 cites W2045134338 @default.
- W1519237973 cites W2050154786 @default.
- W1519237973 cites W2054978125 @default.
- W1519237973 cites W2055403920 @default.
- W1519237973 cites W2058687295 @default.
- W1519237973 cites W2059071424 @default.
- W1519237973 cites W2059337777 @default.
- W1519237973 cites W2060067993 @default.
- W1519237973 cites W2060216716 @default.
- W1519237973 cites W2065172132 @default.
- W1519237973 cites W2065333042 @default.
- W1519237973 cites W2070171027 @default.
- W1519237973 cites W2076510057 @default.
- W1519237973 cites W2079242559 @default.
- W1519237973 cites W2079345912 @default.
- W1519237973 cites W2083305942 @default.
- W1519237973 cites W2084626478 @default.
- W1519237973 cites W2087507850 @default.
- W1519237973 cites W2087705083 @default.
- W1519237973 cites W2095753163 @default.
- W1519237973 cites W2101266783 @default.
- W1519237973 cites W2101524137 @default.
- W1519237973 cites W2105935286 @default.
- W1519237973 cites W2107235439 @default.
- W1519237973 cites W2109780283 @default.
- W1519237973 cites W2115779634 @default.
- W1519237973 cites W2116516945 @default.
- W1519237973 cites W2117613919 @default.
- W1519237973 cites W2121449768 @default.
- W1519237973 cites W2123093300 @default.
- W1519237973 cites W2125024368 @default.
- W1519237973 cites W2127379211 @default.
- W1519237973 cites W2128546265 @default.
- W1519237973 cites W2129708180 @default.
- W1519237973 cites W2134900294 @default.
- W1519237973 cites W2135989320 @default.
- W1519237973 cites W2139008734 @default.
- W1519237973 cites W2139643659 @default.
- W1519237973 cites W2139756965 @default.
- W1519237973 cites W2147258683 @default.
- W1519237973 cites W2149676565 @default.