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- W1519248623 abstract "Nonsynaptic signaling is becoming increasingly appreciated in studies of activity-dependent changes in the nervous system. We investigated the types of neuronal activity that elicit nonsynaptic communication between neurons and glial cells in hippocampal output fibers. High-frequency, but not low-frequency, action potential firing in myelinated CA1 axons of the hippocampus resulted in increased phosphorylation of the oligodendrocyte-specific protein myelin basic protein (MBP). This change was blocked by tetrodotoxin, indicating that axonally generated action potentials were necessary to regulate the phosphorylation state of MBP. Furthermore, scavengers of the reactive oxygen species superoxide and hydrogen peroxide and nitric oxide synthase inhibitors prevented activation of this neuron-glia signaling pathway. These results indicate that, during periods of increased neuronal activity in area CA1 of the hippocampus, reactive oxygen and nitrogen species are generated, which diffuse to neighboring oligodendrocytes and result in post-translational modifications of MBP, a key structural protein in myelin. Thus, in addition to their well-known capacity for activity-dependent neuron-neuron signaling, hippocampal pyramidal neurons possess a mechanism for activity-dependent neuron-glia signaling." @default.
- W1519248623 created "2016-06-24" @default.
- W1519248623 creator A5047825983 @default.
- W1519248623 creator A5053267978 @default.
- W1519248623 date "1999-09-01" @default.
- W1519248623 modified "2023-09-26" @default.
- W1519248623 title "Reactive Oxygen Species Mediate Activity-Dependent Neuron–Glia Signaling in Output Fibers of the Hippocampus" @default.
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- W1519248623 doi "https://doi.org/10.1523/jneurosci.19-17-07241.1999" @default.
- W1519248623 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6782520" @default.
- W1519248623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10460230" @default.
- W1519248623 hasPublicationYear "1999" @default.
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