Matches in SemOpenAlex for { <https://semopenalex.org/work/W1519255610> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1519255610 endingPage "1842" @default.
- W1519255610 startingPage "1839" @default.
- W1519255610 abstract "The effect of sulfasalazine and olsalazine on the transport of [3H]folic acid and of [3H]-methotrexate (MTX) was investigated in organ-cultured endoscopic biopsy specimens of small intestinal mucosa from normal subjects. Biopsy specimens obtained from patients undergoing routine diagnostic upper gastrointestinal endoscopy were organ-cultured at pH5.5 and the effect of these two drugs on the initial rate of uptake of the two folates was determined. Both drugs inhibited the transport of [3H]-folic acid with similar Ki values (1.38 and 1.32 mM for sulfasalazine and olsalazine, respectively). However, the uptake of [3H]MTX was only partially inhibited by sulfasalazine and was unaffected by olsalazine. Sulfasalazine inhibited 26.2% of the total flux of MTX, in close agreement with the fraction of MTX flux that has been shown previously to be inhibited by folic acid. These data corroborate previous findings of heterogeneity of transport of MTX in the mucosa of the human small intestine." @default.
- W1519255610 created "2016-06-24" @default.
- W1519255610 creator A5075976405 @default.
- W1519255610 date "1992-11-01" @default.
- W1519255610 modified "2023-09-23" @default.
- W1519255610 title "Drug interactions in intestinal transport of folic acid and methotrexate" @default.
- W1519255610 cites W1479070774 @default.
- W1519255610 cites W1544317529 @default.
- W1519255610 cites W1721842431 @default.
- W1519255610 cites W1727714355 @default.
- W1519255610 cites W1849170759 @default.
- W1519255610 cites W1898944809 @default.
- W1519255610 cites W1964260529 @default.
- W1519255610 cites W2028301426 @default.
- W1519255610 cites W2069233942 @default.
- W1519255610 cites W2242219632 @default.
- W1519255610 cites W2274848156 @default.
- W1519255610 cites W70353535 @default.
- W1519255610 doi "https://doi.org/10.1016/0006-2952(92)90079-x" @default.
- W1519255610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1360212" @default.
- W1519255610 hasPublicationYear "1992" @default.
- W1519255610 type Work @default.
- W1519255610 sameAs 1519255610 @default.
- W1519255610 citedByCount "19" @default.
- W1519255610 countsByYear W15192556102018 @default.
- W1519255610 crossrefType "journal-article" @default.
- W1519255610 hasAuthorship W1519255610A5075976405 @default.
- W1519255610 hasConcept C126322002 @default.
- W1519255610 hasConcept C185592680 @default.
- W1519255610 hasConcept C2775934546 @default.
- W1519255610 hasConcept C2779134260 @default.
- W1519255610 hasConcept C2779383735 @default.
- W1519255610 hasConcept C2780035454 @default.
- W1519255610 hasConcept C2780479503 @default.
- W1519255610 hasConcept C2781059491 @default.
- W1519255610 hasConcept C2992130864 @default.
- W1519255610 hasConcept C71924100 @default.
- W1519255610 hasConcept C90924648 @default.
- W1519255610 hasConcept C98274493 @default.
- W1519255610 hasConceptScore W1519255610C126322002 @default.
- W1519255610 hasConceptScore W1519255610C185592680 @default.
- W1519255610 hasConceptScore W1519255610C2775934546 @default.
- W1519255610 hasConceptScore W1519255610C2779134260 @default.
- W1519255610 hasConceptScore W1519255610C2779383735 @default.
- W1519255610 hasConceptScore W1519255610C2780035454 @default.
- W1519255610 hasConceptScore W1519255610C2780479503 @default.
- W1519255610 hasConceptScore W1519255610C2781059491 @default.
- W1519255610 hasConceptScore W1519255610C2992130864 @default.
- W1519255610 hasConceptScore W1519255610C71924100 @default.
- W1519255610 hasConceptScore W1519255610C90924648 @default.
- W1519255610 hasConceptScore W1519255610C98274493 @default.
- W1519255610 hasIssue "9" @default.
- W1519255610 hasLocation W15192556101 @default.
- W1519255610 hasLocation W15192556102 @default.
- W1519255610 hasOpenAccess W1519255610 @default.
- W1519255610 hasPrimaryLocation W15192556101 @default.
- W1519255610 hasRelatedWork W1489717960 @default.
- W1519255610 hasRelatedWork W1519255610 @default.
- W1519255610 hasRelatedWork W1792090112 @default.
- W1519255610 hasRelatedWork W1963841012 @default.
- W1519255610 hasRelatedWork W1966616648 @default.
- W1519255610 hasRelatedWork W2027887203 @default.
- W1519255610 hasRelatedWork W2044543470 @default.
- W1519255610 hasRelatedWork W2073104311 @default.
- W1519255610 hasRelatedWork W2570319527 @default.
- W1519255610 hasRelatedWork W3119379866 @default.
- W1519255610 hasVolume "44" @default.
- W1519255610 isParatext "false" @default.
- W1519255610 isRetracted "false" @default.
- W1519255610 magId "1519255610" @default.
- W1519255610 workType "article" @default.