FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1519258957> ?p ?o ?g. }

• W1519258957 endingPage "9" @default.
• W1519258957 startingPage "283" @default.
• W1519258957 abstract "Tuberculosis (tB) and multidrug and extensively drug-resistant (dR) tB are important public health problems that are spreading worldwide. The aims of this study were to determine the sensitivity and specificity of the genotype® mtBdRplus assay from smear-positive clinical specimens and isolates and to explore its possible application in routine work. Clinical samples were previously decontaminated using naoH-n-acetyl-l-cystein or naoH-Clna hypertonic solution for Ziehl-neelsen staining and cultures. The leftover sediments of smear-positive samples were stored at -20 °C, 70 of which were selected to be included in this study according to their dR profile. thirty dR Mycobacterium tuberculosis isolates were also assessed. Sequencing was used as gold standard to detect mutations conferring isoniazid (InH) and rifampicin (RIF) resistance. Valid results were obtained in 94.0 % of the samples and 85.5 % (53/62) of the InH-R samples were properly identified. mutations in the katGS315t gene and inhA C-15t gene promoter region were present in 59.7 % (37/62) and 25.8 % (16/62) of the InH-R samples, respectively. the system could also identify 97.7 % (41/42) of the RIF-R samples; the mutations found were rpoBS531l (66.7 %, 28/42), d516V (19.0 %, 8/42), H526Y and S531p/W (4.8 %, 2/42 each one), and S522l/Q (2.4 %, 1/42). a 98.8 % concordance between the genotype assay and sequencing was obtained. genotype® mtBdRplus has demonstrated to be easy to implement and to perform in clinical laboratories and useful for a rapid detection of dR M. tuberculosis from decontaminated sputa and clinical isolates. Therefore, this assay could be applied as a rapid tool to predict InH-R and/or RIF-R in dR risk cases." @default.
• W1519258957 created "2016-06-24" @default.
• W1519258957 creator A5016411059 @default.
• W1519258957 creator A5057146941 @default.
• W1519258957 creator A5065285990 @default.
• W1519258957 creator A5065898364 @default.
• W1519258957 creator A5089654503 @default.
• W1519258957 creator A5090584689 @default.
• W1519258957 date "2012-12-27" @default.
• W1519258957 modified "2023-09-26" @default.
• W1519258957 title "First evaluation in Argentina of the GenoType® MTBDRplus assay for multidrug-resistant Mycobacterium tuberculosis detection from clinical isolates and specimens." @default.
• W1519258957 cites W1793781539 @default.
• W1519258957 cites W191806160 @default.
• W1519258957 cites W1968593986 @default.
• W1519258957 cites W1979850557 @default.
• W1519258957 cites W1989597041 @default.
• W1519258957 cites W2011753078 @default.
• W1519258957 cites W2033818010 @default.
• W1519258957 cites W2064917085 @default.
• W1519258957 cites W2065963124 @default.
• W1519258957 cites W2068699695 @default.
• W1519258957 cites W2079561839 @default.
• W1519258957 cites W2122261512 @default.
• W1519258957 cites W2139306579 @default.
• W1519258957 cites W2140262510 @default.
• W1519258957 cites W2152642009 @default.
• W1519258957 cites W2153385431 @default.
• W1519258957 cites W2154531864 @default.
• W1519258957 cites W2161217659 @default.
• W1519258957 cites W2162912294 @default.
• W1519258957 cites W2164045886 @default.
• W1519258957 cites W2413540156 @default.
• W1519258957 cites W2477471318 @default.
• W1519258957 cites W2948083005 @default.
• W1519258957 cites W3148983788 @default.
• W1519258957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23267627" @default.
• W1519258957 hasPublicationYear "2012" @default.
• W1519258957 type Work @default.
• W1519258957 sameAs 1519258957 @default.
• W1519258957 citedByCount "7" @default.
• W1519258957 countsByYear W15192589572013 @default.
• W1519258957 countsByYear W15192589572015 @default.
• W1519258957 countsByYear W15192589572016 @default.
• W1519258957 countsByYear W15192589572017 @default.
• W1519258957 countsByYear W15192589572018 @default.
• W1519258957 countsByYear W15192589572020 @default.
• W1519258957 crossrefType "journal-article" @default.
• W1519258957 hasAuthorship W1519258957A5016411059 @default.
• W1519258957 hasAuthorship W1519258957A5057146941 @default.
• W1519258957 hasAuthorship W1519258957A5065285990 @default.
• W1519258957 hasAuthorship W1519258957A5065898364 @default.
• W1519258957 hasAuthorship W1519258957A5089654503 @default.
• W1519258957 hasAuthorship W1519258957A5090584689 @default.
• W1519258957 hasConcept C104317684 @default.
• W1519258957 hasConcept C114851261 @default.
• W1519258957 hasConcept C126322002 @default.
• W1519258957 hasConcept C133936738 @default.
• W1519258957 hasConcept C135763542 @default.
• W1519258957 hasConcept C142724271 @default.
• W1519258957 hasConcept C159047783 @default.
• W1519258957 hasConcept C160798450 @default.
• W1519258957 hasConcept C2776967927 @default.
• W1519258957 hasConcept C2777975735 @default.
• W1519258957 hasConcept C2778607973 @default.
• W1519258957 hasConcept C2780687663 @default.
• W1519258957 hasConcept C2781069245 @default.
• W1519258957 hasConcept C40993552 @default.
• W1519258957 hasConcept C501593827 @default.
• W1519258957 hasConcept C54355233 @default.
• W1519258957 hasConcept C71924100 @default.
• W1519258957 hasConcept C86803240 @default.
• W1519258957 hasConcept C89423630 @default.
• W1519258957 hasConceptScore W1519258957C104317684 @default.
• W1519258957 hasConceptScore W1519258957C114851261 @default.
• W1519258957 hasConceptScore W1519258957C126322002 @default.
• W1519258957 hasConceptScore W1519258957C133936738 @default.
• W1519258957 hasConceptScore W1519258957C135763542 @default.
• W1519258957 hasConceptScore W1519258957C142724271 @default.
• W1519258957 hasConceptScore W1519258957C159047783 @default.
• W1519258957 hasConceptScore W1519258957C160798450 @default.
• W1519258957 hasConceptScore W1519258957C2776967927 @default.
• W1519258957 hasConceptScore W1519258957C2777975735 @default.
• W1519258957 hasConceptScore W1519258957C2778607973 @default.
• W1519258957 hasConceptScore W1519258957C2780687663 @default.
• W1519258957 hasConceptScore W1519258957C2781069245 @default.
• W1519258957 hasConceptScore W1519258957C40993552 @default.
• W1519258957 hasConceptScore W1519258957C501593827 @default.
• W1519258957 hasConceptScore W1519258957C54355233 @default.
• W1519258957 hasConceptScore W1519258957C71924100 @default.
• W1519258957 hasConceptScore W1519258957C86803240 @default.
• W1519258957 hasConceptScore W1519258957C89423630 @default.
• W1519258957 hasIssue "4" @default.
• W1519258957 hasLocation W15192589571 @default.
• W1519258957 hasOpenAccess W1519258957 @default.
• W1519258957 hasPrimaryLocation W15192589571 @default.
• W1519258957 hasRelatedWork W2122261512 @default.
• W1519258957 hasRelatedWork W2132102084 @default.
• W1519258957 hasRelatedWork W2139040924 @default.

• next