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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1519279488> ?p ?o ?g. }

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• W1519279488 startingPage "445" @default.
• W1519279488 abstract "Melanin protects the skin against ultraviolet radiation (UVR) and diverse free radicals. Agents that increase melanin synthesis in melanocytes may reduce UVR-induced skin damage and skin cancer. In the present study, we evaluated the effects of 5,7-dimethoxyflavone (5,7-DMF) on melanogenic protein expression and signalling pathways. We found that 5,7-DMF significantly increased melanin content by upregulating microphthalmia-associated transcription factor and related melanogenic proteins. Additionally, 5,7-DMF increased cAMP levels, which activates a cascade of reactions, such as cAMP responsive element-binding protein and Akt/glycogen synthase kinase-3β (GSK-3β) signalling. Thus, 5,7-DMF may be an effective pigmentation stimulator for photoprotection and hypopigmentation disorders." @default.
• W1519279488 created "2016-06-24" @default.
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• W1519279488 date "2011-03-22" @default.
• W1519279488 modified "2023-10-14" @default.
• W1519279488 title "5,7-Dimethoxyflavone induces melanogenesis in B16F10 melanoma cells through cAMP-dependent signalling" @default.
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• W1519279488 doi "https://doi.org/10.1111/j.1600-0625.2010.01236.x" @default.
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• W1519279488 hasPublicationYear "2011" @default.
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