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- W1519290346 abstract "Abstract The CD19/CD21 complex is an essential B cell coreceptor that functions synergistically to enhance signaling through the B cell Ag receptor in response to T cell-dependent, complement-tagged Ags. In this study, we use a recombinant protein containing three tandemly arranged copies of C3d and the Ag hen egg lysozyme, shown to be a highly effective immunogen in vivo, to evaluate the role of the CD19/CD21 complex in Ag processing in B cells. Evidence is provided that coengagement of the CD19/CD21 complex results in more rapid and efficient production of antigenic peptide/class II complexes as compared with B cell Ag receptor-mediated processing alone. The CD19/CD21 complex does not itself target complement-tagged Ags for processing, but rather appears to influence B cell Ag processing through its signaling function. The ability of the CD19/CD21 complex to augment processing may be an important element of the mechanism by which the CD19/CD21 complex functions to promote B cell responses to T cell-dependent complement-tagged Ags in vivo." @default.
- W1519290346 created "2016-06-24" @default.
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- W1519290346 date "2001-07-01" @default.
- W1519290346 modified "2023-10-03" @default.
- W1519290346 title "The Role of the CD19/CD21 Complex in B Cell Processing and Presentation of Complement-Tagged Antigens" @default.
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- W1519290346 doi "https://doi.org/10.4049/jimmunol.167.1.163" @default.
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