FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1519295067> ?p ?o ?g. }

• W1519295067 endingPage "2968" @default.
• W1519295067 startingPage "2960" @default.
• W1519295067 abstract "Abstract IL-12 and IL-12 antagonist administration to nonobese diabetic (NOD) mice accelerates and prevents insulin-dependent diabetes mellitus (IDDM), respectively. To further define the role of endogenous IL-12 in the development of diabetogenic Th1 cells, IL-12-deficient NOD mice were generated and analyzed. Th1 responses to exogenous Ags were reduced by ∼80% in draining lymph nodes of these mice, and addition of IL-12, but not IL-18, restored Th1 development in vitro, indicating a nonredundant role of IL-12. Moreover, spontaneous Th1 responses to a self Ag, the tyrosine phosphatase-like IA-2, were undetectable in lymphoid organs from IL-12-deficient, in contrast to wild-type, NOD mice. Nevertheless, wild-type and IL-12-deficient NOD mice developed similar insulitis and IDDM. Both in wild-type and IL-12-deficient NOD mice, ∼20% of pancreas-infiltrating CD4+ T cells produced IFN-γ, whereas very few produced IL-10 or IL-4, indicating that IDDM was associated with a type 1 T cell infiltrate in the target organ. T cell recruitment in the pancreas seemed favored in IL-12-deficient NOD mice, as revealed by increased P-selectin ligand expression on pancreas-infiltrating T cells, and this could, at least in part, compensate for the defective Th1 cell pool recruitable from peripheral lymphoid organs. Residual Th1 cells could also accumulate in the pancreas of IL-12-deficient NOD mice because Th2 cells were not induced, in contrast to wild-type NOD mice treated with an IL-12 antagonist. Thus, a regulatory pathway seems necessary to counteract the pathogenic Th1 cells that develop in the absence of IL-12 in a spontaneous chronic progressive autoimmune disease under polygenic control, such as IDDM." @default.
• W1519295067 created "2016-06-24" @default.
• W1519295067 creator A5017901947 @default.
• W1519295067 creator A5032929917 @default.
• W1519295067 creator A5037770300 @default.
• W1519295067 creator A5058458204 @default.
• W1519295067 creator A5073755118 @default.
• W1519295067 creator A5082136074 @default.
• W1519295067 creator A5090687110 @default.
• W1519295067 date "1999-09-01" @default.
• W1519295067 modified "2023-10-18" @default.
• W1519295067 title "Pancreas-Infiltrating Th1 Cells and Diabetes Develop in IL-12-Deficient Nonobese Diabetic Mice" @default.
• W1519295067 cites W1494179057 @default.
• W1519295067 cites W1526621387 @default.
• W1519295067 cites W1527404918 @default.
• W1519295067 cites W1536464807 @default.
• W1519295067 cites W1592262265 @default.
• W1519295067 cites W1597836403 @default.
• W1519295067 cites W1678871737 @default.
• W1519295067 cites W1716317097 @default.
• W1519295067 cites W1894525365 @default.
• W1519295067 cites W1925645192 @default.
• W1519295067 cites W1942668068 @default.
• W1519295067 cites W1963713418 @default.
• W1519295067 cites W1970160145 @default.
• W1519295067 cites W1974264251 @default.
• W1519295067 cites W1978150903 @default.
• W1519295067 cites W1985946203 @default.
• W1519295067 cites W1988820544 @default.
• W1519295067 cites W1989090634 @default.
• W1519295067 cites W1991137313 @default.
• W1519295067 cites W1991524518 @default.
• W1519295067 cites W1991587280 @default.
• W1519295067 cites W1998199590 @default.
• W1519295067 cites W1998595111 @default.
• W1519295067 cites W2005246059 @default.
• W1519295067 cites W2007035944 @default.
• W1519295067 cites W2012628280 @default.
• W1519295067 cites W2017684091 @default.
• W1519295067 cites W2026161448 @default.
• W1519295067 cites W2027544471 @default.
• W1519295067 cites W2029836713 @default.
• W1519295067 cites W2031501484 @default.
• W1519295067 cites W2044585677 @default.
• W1519295067 cites W2050473688 @default.
• W1519295067 cites W2059059286 @default.
• W1519295067 cites W2063053561 @default.
• W1519295067 cites W2075841063 @default.
• W1519295067 cites W2079481583 @default.
• W1519295067 cites W2081041392 @default.
• W1519295067 cites W2087372329 @default.
• W1519295067 cites W2089262366 @default.
• W1519295067 cites W2089749009 @default.
• W1519295067 cites W2091922025 @default.
• W1519295067 cites W2094197485 @default.
• W1519295067 cites W2102440756 @default.
• W1519295067 cites W2104050261 @default.
• W1519295067 cites W2104439753 @default.
• W1519295067 cites W2105808377 @default.
• W1519295067 cites W2108473659 @default.
• W1519295067 cites W2112812475 @default.
• W1519295067 cites W2124870236 @default.
• W1519295067 cites W2125985469 @default.
• W1519295067 cites W2133487448 @default.
• W1519295067 cites W2133604102 @default.
• W1519295067 cites W2140886712 @default.
• W1519295067 cites W2141672711 @default.
• W1519295067 cites W2144077105 @default.
• W1519295067 cites W2154218327 @default.
• W1519295067 cites W2162888477 @default.
• W1519295067 cites W2164924638 @default.
• W1519295067 cites W2168930459 @default.
• W1519295067 cites W2171231066 @default.
• W1519295067 cites W2171831396 @default.
• W1519295067 cites W2230641175 @default.
• W1519295067 cites W4242902586 @default.
• W1519295067 cites W4245135998 @default.
• W1519295067 cites W82670290 @default.
• W1519295067 doi "https://doi.org/10.4049/jimmunol.163.5.2960" @default.
• W1519295067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10453045" @default.
• W1519295067 hasPublicationYear "1999" @default.
• W1519295067 type Work @default.
• W1519295067 sameAs 1519295067 @default.
• W1519295067 citedByCount "75" @default.
• W1519295067 countsByYear W15192950672012 @default.
• W1519295067 countsByYear W15192950672013 @default.
• W1519295067 countsByYear W15192950672014 @default.
• W1519295067 countsByYear W15192950672015 @default.
• W1519295067 countsByYear W15192950672016 @default.
• W1519295067 countsByYear W15192950672017 @default.
• W1519295067 countsByYear W15192950672018 @default.
• W1519295067 countsByYear W15192950672020 @default.
• W1519295067 countsByYear W15192950672021 @default.
• W1519295067 countsByYear W15192950672023 @default.
• W1519295067 crossrefType "journal-article" @default.
• W1519295067 hasAuthorship W1519295067A5017901947 @default.
• W1519295067 hasAuthorship W1519295067A5032929917 @default.
• W1519295067 hasAuthorship W1519295067A5037770300 @default.

• next