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- W1519304503 abstract "Abstract Time course of responses of renal and hepatic carbonic anhydrase activities in microsomal and supernatant fractions to aldosterone and actinomycin D were examined at intervals ranging from 3 to 24 hr after a single administration. Aldosterone in doses of 1 μg/kg and 2 μg/kg injected i.p. temporarily increased renal and hepatic enzymic activities at 2–6 hr after treatment. A larger dose of aldosterone (30 μg/kg) injected s.c. continuously increased renal and hepatic carbonic anhydrase activity until 24 hr after injection. After i.p. injection of actinomycin D (300 μg/kg), renal carbonic anhydrase activity was decreased gradually until 6 hr and thereafter returned to normal values, while hepatic carbonic anhydrase activity was increased gradually until 6 hr and thereafter returned to normal values. The stimulatory effect of aldosterone on renal carbonic anhydrase activity was blocked by concurrent treatment with actinomycin D and the inhibitory effect of actinomycin D on this enzymic activity was blocked conversely by concurrent treatment with aldosterone." @default.
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- W1519304503 date "1971-04-01" @default.
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- W1519304503 title "Experimental studies on the carbonic anhydrase activity-XIII" @default.
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- W1519304503 doi "https://doi.org/10.1016/0006-2952(71)90039-6" @default.
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