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• W1519401084 abstract "Caries (dental decay) is a disease of the hard tissues of the teeth caused by an imbalance, over time, in the interactions between cariogenic bacteria in dental plaque and fermentable carbohydrates (mainly sugars). The use of fluoride toothpaste is the primary intervention for the prevention of caries.To determine the relative effectiveness of fluoride toothpastes of different concentrations in preventing dental caries in children and adolescents, and to examine the potentially modifying effects of baseline caries level and supervised toothbrushing.A search was undertaken on Cochrane Oral Health Group's Trials Register, CENTRAL, MEDLINE and several other databases. Reference lists of articles were also searched. Date of the most recent searches: 8 June 2009.Randomised controlled trials and cluster-randomised controlled trials comparing fluoride toothpaste with placebo or fluoride toothpaste of a different concentration in children up to 16 years of age with a follow-up period of at least 1 year. The primary outcome was caries increment in the permanent or deciduous dentition as measured by the change in decayed, (missing), filled tooth surfaces (D(M)FS/d(m)fs) from baseline.Inclusion of studies, data extraction and quality assessment were undertaken independently and in duplicate by two members of the review team. Disagreements were resolved by discussion and consensus or by a third party. The primary effect measure was the prevented fraction (PF), the caries increment of the control group minus the caries increment of the treatment group, expressed as a proportion of the caries increment in the control group. Where it was appropriate to pool data, network meta-analysis, network meta-regression or meta-analysis models were used. Potential sources of heterogeneity were specified a priori and examined through random-effects meta-regression analysis where appropriate.75 studies were included, of which 71 studies comprising 79 trials contributed data to the network meta-analysis, network meta-regression or meta-analysis.For the 66 studies (74 trials) that contributed to the network meta-analysis of D(M)FS in the mixed or permanent dentition, the caries preventive effect of fluoride toothpaste increased significantly with higher fluoride concentrations (D(M)FS PF compared to placebo was 23% (95% credible interval (CrI) 19% to 27%) for 1000/1055/1100/1250 parts per million (ppm) concentrations rising to 36% (95% CrI 27% to 44%) for toothpastes with a concentration of 2400/2500/2800 ppm), but concentrations of 440/500/550 ppm and below showed no statistically significant effect when compared to placebo. There is some evidence of a dose response relationship in that the PF increased as the fluoride concentration increased from the baseline although this was not always statistically significant. The effect of fluoride toothpaste also increased with baseline level of D(M)FS and supervised brushing, though this did not reach statistical significance. Six studies assessed the effects of fluoride concentrations on the deciduous dentition with equivocal results dependent upon the fluoride concentrations compared and the outcome measure. Compliance with treatment regimen and unwanted effects was assessed in only a minority of studies. When reported, no differential compliance was observed and unwanted effects such as soft tissue damage and tooth staining were minimal.This review confirms the benefits of using fluoride toothpaste in preventing caries in children and adolescents when compared to placebo, but only significantly for fluoride concentrations of 1000 ppm and above. The relative caries preventive effects of fluoride toothpastes of different concentrations increase with higher fluoride concentration. The decision of what fluoride levels to use for children under 6 years should be balanced with the risk of fluorosis." @default.
• W1519401084 created "2016-06-24" @default.
• W1519401084 creator A5012543262 @default.
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• W1519401084 creator A5041128185 @default.
• W1519401084 creator A5077243752 @default.
• W1519401084 date "2010-01-20" @default.
• W1519401084 modified "2023-10-18" @default.
• W1519401084 title "Fluoride toothpastes of different concentrations for preventing dental caries in children and adolescents" @default.
• W1519401084 cites W1482470285 @default.
• W1519401084 cites W1524298720 @default.
• W1519401084 cites W1553060211 @default.
• W1519401084 cites W1555243689 @default.
• W1519401084 cites W1596484239 @default.
• W1519401084 cites W1598602811 @default.
• W1519401084 cites W1691330820 @default.
• W1519401084 cites W1965068516 @default.
• W1519401084 cites W1966170631 @default.
• W1519401084 cites W1966670358 @default.
• W1519401084 cites W1969338297 @default.
• W1519401084 cites W1971028219 @default.
• W1519401084 cites W1971798426 @default.
• W1519401084 cites W1973430480 @default.
• W1519401084 cites W1973700396 @default.
• W1519401084 cites W1977029452 @default.
• W1519401084 cites W1977512345 @default.
• W1519401084 cites W1978471038 @default.
• W1519401084 cites W1979010856 @default.
• W1519401084 cites W1981457914 @default.
• W1519401084 cites W1983544303 @default.
• W1519401084 cites W1986112539 @default.
• W1519401084 cites W1987221162 @default.
• W1519401084 cites W1988520034 @default.
• W1519401084 cites W1989120926 @default.
• W1519401084 cites W1990870198 @default.
• W1519401084 cites W1997432766 @default.
• W1519401084 cites W1998364091 @default.
• W1519401084 cites W2000093923 @default.
• W1519401084 cites W2000270362 @default.
• W1519401084 cites W2001291729 @default.
• W1519401084 cites W2002944792 @default.
• W1519401084 cites W2005499206 @default.
• W1519401084 cites W2005982505 @default.
• W1519401084 cites W2006809367 @default.
• W1519401084 cites W2006982795 @default.
• W1519401084 cites W2014059128 @default.
• W1519401084 cites W2016219035 @default.
• W1519401084 cites W2017172484 @default.
• W1519401084 cites W2017802514 @default.
• W1519401084 cites W2017861463 @default.
• W1519401084 cites W2017916104 @default.
• W1519401084 cites W2021818076 @default.
• W1519401084 cites W2024500523 @default.
• W1519401084 cites W2026736990 @default.
• W1519401084 cites W2027507008 @default.
• W1519401084 cites W2027778479 @default.
• W1519401084 cites W2027954288 @default.
• W1519401084 cites W2028638239 @default.
• W1519401084 cites W2030594254 @default.
• W1519401084 cites W2032113091 @default.
• W1519401084 cites W2034246389 @default.
• W1519401084 cites W2039192072 @default.
• W1519401084 cites W2039254815 @default.
• W1519401084 cites W2039312527 @default.
• W1519401084 cites W2042426019 @default.
• W1519401084 cites W2048123270 @default.
• W1519401084 cites W2048502206 @default.
• W1519401084 cites W2049487822 @default.
• W1519401084 cites W2054438292 @default.
• W1519401084 cites W2056928461 @default.
• W1519401084 cites W2057728460 @default.
• W1519401084 cites W2058665175 @default.
• W1519401084 cites W2064643513 @default.
• W1519401084 cites W2065589388 @default.
• W1519401084 cites W2066231887 @default.
• W1519401084 cites W2068631347 @default.
• W1519401084 cites W2069529141 @default.
• W1519401084 cites W2070397373 @default.
• W1519401084 cites W2071438887 @default.
• W1519401084 cites W2071935901 @default.
• W1519401084 cites W2072696814 @default.
• W1519401084 cites W2073051183 @default.
• W1519401084 cites W2074155835 @default.
• W1519401084 cites W2075983175 @default.
• W1519401084 cites W2076885760 @default.
• W1519401084 cites W2080688631 @default.
• W1519401084 cites W2088011502 @default.
• W1519401084 cites W2088567629 @default.
• W1519401084 cites W2089512512 @default.
• W1519401084 cites W2092238860 @default.
• W1519401084 cites W2094179065 @default.
• W1519401084 cites W2107043010 @default.
• W1519401084 cites W2109498615 @default.
• W1519401084 cites W2113861507 @default.
• W1519401084 cites W2115123562 @default.
• W1519401084 cites W2133820221 @default.
• W1519401084 cites W2135508699 @default.
• W1519401084 cites W2135760063 @default.

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