Matches in SemOpenAlex for { <https://semopenalex.org/work/W1519447167> ?p ?o ?g. }
- W1519447167 endingPage "13" @default.
- W1519447167 startingPage "1" @default.
- W1519447167 abstract "Genome instability and impaired DNA repair are hallmarks of carcinogenesis. The study was aimed at evaluating the DNA damage response in H 2 O 2 -treated lymphocytes using the alkaline comet assay in bladder cancer (BC) patients as compared to clinically healthy controls, elderly persons, and individuals with chronic inflammations. Polymorphism in DNA repair genes involved in nucleotide excision repair (NER) and base excision repair (BER) was studied using the PCR-RFLP method in the Belarusian population to elucidate the possible association of their variations with both bladder cancer risk and clinicopathological features of tumors. The increased level of H 2 O 2 -induced DNA damage and a higher proportion of individuals sensitive to oxidative stress were found among BC patients as compared to other groups under study. Heterozygosity in the XPD gene (codon 751) increased cancer risk: OR (95% CI) = 1.36 (1.03–1.81),<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.031</mml:mn></mml:math>. The frequency of the XPD 312Asn allele was significantly higher in T ≥ 2 high grade than in T ≥ 2 low grade tumors<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mfenced separators=|><mml:mrow><mml:mi>p</mml:mi><mml:mo>=</mml:mo><mml:mn>0.036</mml:mn></mml:mrow></mml:mfenced></mml:mrow></mml:math>; the ERCC6 1097Val/Val genotype was strongly associated with muscle-invasive tumors. Combinations of homozygous wild type alleles occurred with the increased frequency in patients with non-muscle-invasive tumors suggesting that the maintenance of normal DNA repair activity may prevent cancer progression." @default.
- W1519447167 created "2016-06-24" @default.
- W1519447167 creator A5011405721 @default.
- W1519447167 creator A5035022786 @default.
- W1519447167 creator A5047540131 @default.
- W1519447167 creator A5060040173 @default.
- W1519447167 creator A5086859649 @default.
- W1519447167 creator A5091174350 @default.
- W1519447167 date "2016-01-01" @default.
- W1519447167 modified "2023-10-14" @default.
- W1519447167 title "The Cellular Response to Oxidatively Induced DNA Damage and Polymorphism of Some DNA Repair Genes Associated with Clinicopathological Features of Bladder Cancer" @default.
- W1519447167 cites W1543746024 @default.
- W1519447167 cites W184494277 @default.
- W1519447167 cites W1903265775 @default.
- W1519447167 cites W1920197602 @default.
- W1519447167 cites W1968780545 @default.
- W1519447167 cites W1977449047 @default.
- W1519447167 cites W1981582641 @default.
- W1519447167 cites W1982823937 @default.
- W1519447167 cites W1983540771 @default.
- W1519447167 cites W1986482438 @default.
- W1519447167 cites W1993583543 @default.
- W1519447167 cites W1994123067 @default.
- W1519447167 cites W1996134291 @default.
- W1519447167 cites W1997446610 @default.
- W1519447167 cites W1997909925 @default.
- W1519447167 cites W1999387657 @default.
- W1519447167 cites W2003416292 @default.
- W1519447167 cites W2015725762 @default.
- W1519447167 cites W2016654554 @default.
- W1519447167 cites W2021183792 @default.
- W1519447167 cites W2022833451 @default.
- W1519447167 cites W2025147350 @default.
- W1519447167 cites W2025810782 @default.
- W1519447167 cites W2026347115 @default.
- W1519447167 cites W2026827146 @default.
- W1519447167 cites W2032125509 @default.
- W1519447167 cites W2036818597 @default.
- W1519447167 cites W2039999094 @default.
- W1519447167 cites W2040935933 @default.
- W1519447167 cites W2042447895 @default.
- W1519447167 cites W2051364656 @default.
- W1519447167 cites W2056831041 @default.
- W1519447167 cites W2059971436 @default.
- W1519447167 cites W2064352891 @default.
- W1519447167 cites W2066411725 @default.
- W1519447167 cites W2068523052 @default.
- W1519447167 cites W2071396949 @default.
- W1519447167 cites W2073806145 @default.
- W1519447167 cites W2081685795 @default.
- W1519447167 cites W2082877032 @default.
- W1519447167 cites W2082919291 @default.
- W1519447167 cites W2088646749 @default.
- W1519447167 cites W2089694648 @default.
- W1519447167 cites W2090733779 @default.
- W1519447167 cites W2096136751 @default.
- W1519447167 cites W2096785399 @default.
- W1519447167 cites W2097560466 @default.
- W1519447167 cites W2098114129 @default.
- W1519447167 cites W2105483695 @default.
- W1519447167 cites W2106625186 @default.
- W1519447167 cites W2118682325 @default.
- W1519447167 cites W2123250752 @default.
- W1519447167 cites W2125031929 @default.
- W1519447167 cites W2125095236 @default.
- W1519447167 cites W2126902508 @default.
- W1519447167 cites W2136108195 @default.
- W1519447167 cites W2137676099 @default.
- W1519447167 cites W2139512095 @default.
- W1519447167 cites W2147802873 @default.
- W1519447167 cites W2148713962 @default.
- W1519447167 cites W2149312363 @default.
- W1519447167 cites W2159558881 @default.
- W1519447167 cites W2160866940 @default.
- W1519447167 cites W2161308107 @default.
- W1519447167 cites W2164670061 @default.
- W1519447167 cites W2168042509 @default.
- W1519447167 cites W2290238862 @default.
- W1519447167 cites W2401652829 @default.
- W1519447167 cites W2414310810 @default.
- W1519447167 cites W4241361545 @default.
- W1519447167 doi "https://doi.org/10.1155/2016/5710403" @default.
- W1519447167 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4663333" @default.
- W1519447167 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26649138" @default.
- W1519447167 hasPublicationYear "2016" @default.
- W1519447167 type Work @default.
- W1519447167 sameAs 1519447167 @default.
- W1519447167 citedByCount "13" @default.
- W1519447167 countsByYear W15194471672016 @default.
- W1519447167 countsByYear W15194471672017 @default.
- W1519447167 countsByYear W15194471672018 @default.
- W1519447167 countsByYear W15194471672019 @default.
- W1519447167 countsByYear W15194471672020 @default.
- W1519447167 countsByYear W15194471672021 @default.
- W1519447167 countsByYear W15194471672023 @default.
- W1519447167 crossrefType "journal-article" @default.
- W1519447167 hasAuthorship W1519447167A5011405721 @default.
- W1519447167 hasAuthorship W1519447167A5035022786 @default.