Matches in SemOpenAlex for { <https://semopenalex.org/work/W1519461621> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1519461621 abstract "The crystal structure of glutamine synthetase (GS) from Mycobacterium tuberculosis determined at 2.4 A resolution reveals citrate and AMP bound in the active site. The structure was refined with strict 24-fold noncrystallographic symmetry (NCS) constraints and has an R-factor of 22.7% and an R-free of 25.5%. Multicopy refinement using 10 atomic models and strict 24-fold NCS constraints further reduced the R-factor to 20.4% and the R-free to 23.2%. The multicopy model demonstrates the range of atomic displacements of catalytic and regulatory loops in glutamine synthesis, simulating loop motions. A comparison with loop positions in substrate complexes of GS from Salmonella typhimurium shows that the Asp50 and Glu327 loops close over the active site during catalysis. These loop closures are preceded by a conformational change of the Glu209 β-strand upon metal ion or ATP binding that converts the enzyme from a relaxed to a taut state. We propose a model of the GS regulatory mechanism based on the loop motions..." @default.
- W1519461621 created "2016-06-24" @default.
- W1519461621 creator A5002771810 @default.
- W1519461621 creator A5080439570 @default.
- W1519461621 creator A5080780553 @default.
- W1519461621 date "2002-01-01" @default.
- W1519461621 modified "2023-10-01" @default.
- W1519461621 title "MULTICOPY CRYSTALLOGRAPHIC REFINEMENT OF A RELAXED GLUTAMINE SYNTHETASE FROM MYCOBACTERIUM TUBERCULOSIS HIGHLIGHTS FLEXIBLE LOOPS IN THE ENZYMATIC MECHANISM AND ITS REGULATION" @default.
- W1519461621 hasPublicationYear "2002" @default.
- W1519461621 type Work @default.
- W1519461621 sameAs 1519461621 @default.
- W1519461621 citedByCount "0" @default.
- W1519461621 crossrefType "journal-article" @default.
- W1519461621 hasAuthorship W1519461621A5002771810 @default.
- W1519461621 hasAuthorship W1519461621A5080439570 @default.
- W1519461621 hasAuthorship W1519461621A5080780553 @default.
- W1519461621 hasConcept C107824862 @default.
- W1519461621 hasConcept C12554922 @default.
- W1519461621 hasConcept C142724271 @default.
- W1519461621 hasConcept C181199279 @default.
- W1519461621 hasConcept C185592680 @default.
- W1519461621 hasConcept C2777339483 @default.
- W1519461621 hasConcept C2777975735 @default.
- W1519461621 hasConcept C2779289688 @default.
- W1519461621 hasConcept C2779349466 @default.
- W1519461621 hasConcept C2781069245 @default.
- W1519461621 hasConcept C41183919 @default.
- W1519461621 hasConcept C515207424 @default.
- W1519461621 hasConcept C55493867 @default.
- W1519461621 hasConcept C71240020 @default.
- W1519461621 hasConcept C71924100 @default.
- W1519461621 hasConcept C8010536 @default.
- W1519461621 hasConcept C86803240 @default.
- W1519461621 hasConceptScore W1519461621C107824862 @default.
- W1519461621 hasConceptScore W1519461621C12554922 @default.
- W1519461621 hasConceptScore W1519461621C142724271 @default.
- W1519461621 hasConceptScore W1519461621C181199279 @default.
- W1519461621 hasConceptScore W1519461621C185592680 @default.
- W1519461621 hasConceptScore W1519461621C2777339483 @default.
- W1519461621 hasConceptScore W1519461621C2777975735 @default.
- W1519461621 hasConceptScore W1519461621C2779289688 @default.
- W1519461621 hasConceptScore W1519461621C2779349466 @default.
- W1519461621 hasConceptScore W1519461621C2781069245 @default.
- W1519461621 hasConceptScore W1519461621C41183919 @default.
- W1519461621 hasConceptScore W1519461621C515207424 @default.
- W1519461621 hasConceptScore W1519461621C55493867 @default.
- W1519461621 hasConceptScore W1519461621C71240020 @default.
- W1519461621 hasConceptScore W1519461621C71924100 @default.
- W1519461621 hasConceptScore W1519461621C8010536 @default.
- W1519461621 hasConceptScore W1519461621C86803240 @default.
- W1519461621 hasLocation W15194616211 @default.
- W1519461621 hasOpenAccess W1519461621 @default.
- W1519461621 hasPrimaryLocation W15194616211 @default.
- W1519461621 hasRelatedWork W1927998362 @default.
- W1519461621 hasRelatedWork W1969609100 @default.
- W1519461621 hasRelatedWork W1992495932 @default.
- W1519461621 hasRelatedWork W2001139474 @default.
- W1519461621 hasRelatedWork W2016982082 @default.
- W1519461621 hasRelatedWork W2018354902 @default.
- W1519461621 hasRelatedWork W2019956959 @default.
- W1519461621 hasRelatedWork W2031293229 @default.
- W1519461621 hasRelatedWork W2047229122 @default.
- W1519461621 hasRelatedWork W2048764471 @default.
- W1519461621 hasRelatedWork W2066849290 @default.
- W1519461621 hasRelatedWork W2096814133 @default.
- W1519461621 hasRelatedWork W2114867389 @default.
- W1519461621 hasRelatedWork W2157576189 @default.
- W1519461621 hasRelatedWork W2196301765 @default.
- W1519461621 hasRelatedWork W2279524587 @default.
- W1519461621 hasRelatedWork W2418204269 @default.
- W1519461621 hasRelatedWork W2583368800 @default.
- W1519461621 hasRelatedWork W2793903213 @default.
- W1519461621 hasRelatedWork W319682455 @default.
- W1519461621 hasVolume "338" @default.
- W1519461621 isParatext "false" @default.
- W1519461621 isRetracted "false" @default.
- W1519461621 magId "1519461621" @default.
- W1519461621 workType "article" @default.