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• W1519463872 abstract "The identification of central neuronal loci that command complex and coordinated behavioral expression offers the opportunity to study basic neural mechanisms that determine whether and under what conditions a specific behavior is expressed. It was previously shown in the isolated nervous system of Pleurobranchaea that the bilaterally paired ventral white cells (VWCs) of the buccal ganglion drive cyclic motor output in the neural network recorded in cut nerve roots to the buccal mass during prolonged endogenous burst episodes (Gillette, R., M. U. Gillette, and W. J. Davis (1978) Sot. Neurosci. Abstr. 4: 1210, (1980) J. Neurophysiol. 43: 669-685). Such burst episodes are also inducible by CAMP and its agonists (Gillette, M. U., R. Gillette, and W. J. Davis (1978) Sot. Neurosci. Abstr. 4: 1209; Gillette, R., M. U. Gillette, and W. J. Davis (1982) J. Comp. Physiol. 146: 461-470). The behavioral significance of the activity driven by the VWCs and the nature of their normal extrinsic activators has been a subject for speculation (Gillette, R., M. U. Gillette, and W. J. Davis (1978) Sot. Neurosci. Abstr. 4: 1210, (1980) J. Neurophysiol. 43: 669-685; McClellan, A. D. (1980) Ph.D. thesis, Case Western Reserve University; Croll, R. P., and W. J. Davis (1982) J. Comp. Physiol. 147: 143-153) but has remained to be established by exact specification of cell activity during behavior. In an anterior hemi-animal preparation, which responds to appetitive and emetic stimuli with appropriate behavior, appetitive (food) stimuli, but not emetic substances, activate the previously quiescent VWCs. This activation is characterized by slow depolarization of the membrane potential accompanied by short rhythmic bursts (5 to 8 spikes); it culminates in a prolonged burst episode (sustained depolarization and spiking at 3 to 5 Hz for 0.7 to 5.0 min). Activation of a VWC by squid homogenate resembles in detail the activation of the cell by CAMP and its agonists (M. Gillette, submitted for publication). Appetitive substances can activate the VWCs via stimulation of the oral veil, but they are most effective in the buccal cavity. During the prolonged burst episode activated by squid homogenate, at the time the spike has broadened appreciably, the VWCs begin to drive the extreme retraction/protraction cycles of the radula that are characteristic of feeding behavior. This is consistent with earlier work which demonstrated that spike broadening during the burst is obligatory for driving motor output in the isolated nervous system (Gillette, R., M. U. Gillette, and W. J. Davis (1980) J. Neurophysiol. 43: 669-685). Simultaneously, in concerted action via their peripheral axons, the VWCs stimulate opening of a sphincter-like buccal-esophageal constriction, as well as marked longitudinal contraction and circular dilation of the esophagus, which is a food storage organ. During prolonged VWC burst episodes, solid food material is progressively moved from the buccal cavity into this shortened esophagus by the extreme retraction/protraction movements of the radula, confirming the ingestive nature of this motor pattern. Emetic substances applied to the oral veil or buccal cavity were never observed to produce extensive or prolonged spike activity, nor did they result in bursting of the VWCs. Emetic stimuli produce cyclic buccal mass movements distinctly different from feeding which we interpret as 1 This work was supported by a research grant from the American University of Washington for facilities used in some studies; and Philosophical Society to M. U. G. and National Science Foundation especially Dr. Vera Fretter for her early guidance in molluscan biology. Grant BNS-79-18329 to R. G. We thank Dr. C. L. Prosser, J. London, * To whom correspondence should be addressed, at Department of D. Green, Dr. M. P. Morse, and Dr. F. Delcomyn for helpful discussion Physiology and Biophysics, 524 Burrill Hall, University of Illinois, and critical reading of the manscript; Friday Harbor Laboratories, Urbana, IL 61801." @default.
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• W1519463872 date "1983-09-01" @default.
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• W1519463872 title "Bursting neurons command consummatory feeding behavior and coordinated visceral receptivity in the predatory mollusk Pleurobranchaea" @default.
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• W1519463872 doi "https://doi.org/10.1523/jneurosci.03-09-01791.1983" @default.
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