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- W1519492252 abstract "In this paper the effect of ACTH 1-24 is described on one of the “early events” occurring during T cell activation: the rise in the concentration of cytosolic free calcium. The increase in cytosolic free calcium induced by concanavalin A or by a monoclonal antibody with specificity for the T cell receptor-T3 complex could be modulated by physiological concentrations of ACTH 1-24. The modulation of the response appeared to be dose dependent. The effect of ACTH 1-24 was maximal at 10−10 M. No effect of ACTH 1-24 was observed on the basal level of cytosolic free calcium. These results indicate that physiological doses of ACTH can interfere with the responsiveness of T cells to mitogenic and antigenic stimuli." @default.
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- W1519492252 date "1988-03-01" @default.
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- W1519492252 title "Modulation of the immune response by proopiomelanocortin derived peptides" @default.
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- W1519492252 doi "https://doi.org/10.1016/0889-1591(88)90006-2" @default.
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