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- W1519549916 abstract "Summary The polycationic drugs 2-chloro-4′, 4″-bis(2-imidazolin-2-yl)terephthalanilide (NSC 38280) 3 and methylglyoxal bis(guanylhydrazone) (MeGAG) behaveas mitochondrial poisons during therapy of the L1210 tumor. Cellular respiration is partly inhibited and the phosphorylation of isolated mitochondria is uncoupled. In common with 2,4-dinitrophenol, the drugs selectively inhibit acetate incorporation into lipid, and under limited circumstances they can abolish the cellular pools of ATP. The mitochondrial effects are: ( a ) potentiated during synergistic therapy with MeGAG and stilbamidine or hydroxystilbamidine, ( b ) abolished when the antitumor effect of MeGAG is antagonized by spermidine, and ( c ) not present during treatment with the therapeutically ineffective dimethylglyoxal bis(guanylhydrazone) or with therapeutically effective but distant congeners of NSC 38280. The tumor can compensate for the loss of its aerobic energy supply with fermentative sources of energy from the host. Antimitochondrial action thus may underlie many of the physiologic effects of these drugs, and a mitochondrial function other than the supply of ATP may be involved in their antitumor action." @default.
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- W1519549916 date "1966-01-01" @default.
- W1519549916 modified "2023-09-23" @default.
- W1519549916 title "The antimitochondrial action of 2-choloro-4', 4-bis(2-imidazolin-2-yl)terephthalanilide and methylglyoxal bis(guanylhydrazone)." @default.
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