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- W1519609261 abstract "Top of pageAbstractGene delivery to the inner ear has the potential to treat hearing loss and balance disorders. A number of studies have shown that adenovirus vectors can transduce sensory and non-sensensory cells within the inner ear. In addition, the expression of growth factors and regulatory genes has been shown to have biological effects. As more candidate therapeutic genes are being discovered, further understanding of the mechanisms involved in adenoviral vector transduction of the inner ear is needed. Multiply deficient and targeted adenovirus vectors have the potential to enhance safety and efficacy of a gene delivery candidate to treat hearing and balance disorders. The advantages that multiply deficient adenoviral vectors deleted of E1A, E1B, E3 and E4 for gene delivery to the inner ear have been shown and the ability of these vectors with modified capsids to specifically transduce the inner ear will be discussed." @default.
- W1519609261 created "2016-06-24" @default.
- W1519609261 date "2004-05-01" @default.
- W1519609261 modified "2023-09-25" @default.
- W1519609261 title "Mechanisms of adenovirus vector gene delivery to the inner ear" @default.
- W1519609261 doi "https://doi.org/10.1016/j.ymthe.2004.06.671" @default.
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