FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1519706104> ?p ?o ?g. }

• W1519706104 endingPage "5985" @default.
• W1519706104 startingPage "5979" @default.
• W1519706104 abstract "Receptor-mediated activation of a G-protein-coupled inwardly rectifying potassium channel (GIRK) is a common mechanism for synaptic modulation in the CNS. However, evidence for metabotropic glutamate receptor (mGluR) activation of GIRK is virtually nonexistent, despite the widespread and overlapping distribution of these proteins. We examined this apparent paradox by coexpressing mGluRs 1a, 2, and 7 with the GIRK subunits Kir3.1 and Kir3.4 in Xenopus oocytes. Functional expression of GIRK was confirmed by coexpression with the D2 dopamine receptor that is known to activate GIRK in neurons. Agonist activation of each of the three mGluRs evoked inward potassium currents in symmetrical KCI solutions. The current amplitudes evoked by mGluR1a, mGluR2, and D2 were comparable, whereas mGluR7 currents were somewhat smaller. mGluR1a-evoked GIRK currents were not blocked in BAPTA-treated oocytes, demonstrating that GIRK activation was distinct from phospholipase C-mediated activation of the endogenous calcium-dependent chloride current (lCaCl). Pertussis toxin (PTX) treatment significantly reduced both the mGluR and D2 receptor-evoked GIRK currents. In oocytes in which mGluR2 and D2 were coexpressed, activation of mGluR2 occluded additional D2 receptor current, indicating that mGluR2 and D2 receptor coupling to GIRK involves a common G-protein. The efficient coupling of mGluRs to GIRK in oocytes suggests either that mGluR activation of GIRK has been overlooked in neurons or possibly that mGluRs are excluded from GIRK-containing microdomains." @default.
• W1519706104 created "2016-06-24" @default.
• W1519706104 creator A5019663751 @default.
• W1519706104 creator A5030130178 @default.
• W1519706104 creator A5033661333 @default.
• W1519706104 date "1996-10-01" @default.
• W1519706104 modified "2023-10-17" @default.
• W1519706104 title "Metabotropic Glutamate Receptors Activate G-Protein-Coupled Inwardly Rectifying Potassium Channels in<b><i>Xenopus</i></b>Oocytes" @default.
• W1519706104 cites W1503789839 @default.
• W1519706104 cites W1515479627 @default.
• W1519706104 cites W1579285271 @default.
• W1519706104 cites W1582905488 @default.
• W1519706104 cites W1586263106 @default.
• W1519706104 cites W1595843790 @default.
• W1519706104 cites W1600728835 @default.
• W1519706104 cites W1614343476 @default.
• W1519706104 cites W1735016861 @default.
• W1519706104 cites W1777046844 @default.
• W1519706104 cites W1893612865 @default.
• W1519706104 cites W1934687632 @default.
• W1519706104 cites W1956954604 @default.
• W1519706104 cites W1965649191 @default.
• W1519706104 cites W1967777525 @default.
• W1519706104 cites W1973613428 @default.
• W1519706104 cites W1973715749 @default.
• W1519706104 cites W1985001613 @default.
• W1519706104 cites W1992904711 @default.
• W1519706104 cites W1996342183 @default.
• W1519706104 cites W1998020090 @default.
• W1519706104 cites W2001567144 @default.
• W1519706104 cites W2006958480 @default.
• W1519706104 cites W2007239691 @default.
• W1519706104 cites W2009809272 @default.
• W1519706104 cites W2020425432 @default.
• W1519706104 cites W2025852280 @default.
• W1519706104 cites W2026339353 @default.
• W1519706104 cites W2028247996 @default.
• W1519706104 cites W2033188783 @default.
• W1519706104 cites W2037335023 @default.
• W1519706104 cites W2039498326 @default.
• W1519706104 cites W2039898903 @default.
• W1519706104 cites W2043166209 @default.
• W1519706104 cites W2043327777 @default.
• W1519706104 cites W2044364856 @default.
• W1519706104 cites W2049513959 @default.
• W1519706104 cites W2058083387 @default.
• W1519706104 cites W2058205481 @default.
• W1519706104 cites W2058606373 @default.
• W1519706104 cites W2059188064 @default.
• W1519706104 cites W2061858869 @default.
• W1519706104 cites W2065559879 @default.
• W1519706104 cites W2066439205 @default.
• W1519706104 cites W2067854932 @default.
• W1519706104 cites W2070027885 @default.
• W1519706104 cites W2072818925 @default.
• W1519706104 cites W2074390596 @default.
• W1519706104 cites W2078119356 @default.
• W1519706104 cites W2078935283 @default.
• W1519706104 cites W2079832005 @default.
• W1519706104 cites W2079837171 @default.
• W1519706104 cites W2085210285 @default.
• W1519706104 cites W2089592191 @default.
• W1519706104 cites W2091620719 @default.
• W1519706104 cites W2095858175 @default.
• W1519706104 cites W2106016755 @default.
• W1519706104 cites W2108302201 @default.
• W1519706104 cites W2129933607 @default.
• W1519706104 cites W2164293375 @default.
• W1519706104 cites W2175877739 @default.
• W1519706104 cites W2283440353 @default.
• W1519706104 cites W2040456704 @default.
• W1519706104 cites W2342836466 @default.
• W1519706104 doi "https://doi.org/10.1523/jneurosci.16-19-05979.1996" @default.
• W1519706104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6579160" @default.
• W1519706104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8815880" @default.
• W1519706104 hasPublicationYear "1996" @default.
• W1519706104 type Work @default.
• W1519706104 sameAs 1519706104 @default.
• W1519706104 citedByCount "106" @default.
• W1519706104 countsByYear W15197061042012 @default.
• W1519706104 countsByYear W15197061042013 @default.
• W1519706104 countsByYear W15197061042014 @default.
• W1519706104 countsByYear W15197061042015 @default.
• W1519706104 countsByYear W15197061042016 @default.
• W1519706104 countsByYear W15197061042017 @default.
• W1519706104 countsByYear W15197061042018 @default.
• W1519706104 countsByYear W15197061042019 @default.
• W1519706104 countsByYear W15197061042020 @default.
• W1519706104 countsByYear W15197061042021 @default.
• W1519706104 countsByYear W15197061042022 @default.
• W1519706104 crossrefType "journal-article" @default.
• W1519706104 hasAuthorship W1519706104A5019663751 @default.
• W1519706104 hasAuthorship W1519706104A5030130178 @default.
• W1519706104 hasAuthorship W1519706104A5033661333 @default.
• W1519706104 hasBestOaLocation W15197061041 @default.
• W1519706104 hasConcept C104317684 @default.
• W1519706104 hasConcept C119128870 @default.
• W1519706104 hasConcept C12554922 @default.

• next