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- W1519726308 abstract "This chapter describes methods for the design and isolation of gene-targeted and gene-trapped embryonic stem (ES) cell lines. In addition, morula aggregation, a procedure alternative to the classic microinjection of ES cells into the blastocysts, is described, and its performance is discussed in comparison with microinjection methods. Adult mice develop normally from these embryos and ES cells contribute to all tissues, including the germline. The unique characteristics allow the introduction of foreign DNA, the screening for rare integration events in ES cells, and the generation of ES cell-derived mouse strains. This strategy has been successfully used for gene targeting by homologous recombination, which has become a powerful tool to study gene function. By this procedure, designed mutations are introduced into particular genes, and mouse lines carrying the mutated allele are generated. In addition, ES cells have been used for the random mutagenesis of the mouse genome by the insertion of gene and enhancer trap vectors." @default.
- W1519726308 created "2016-06-24" @default.
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- W1519726308 date "1997-01-01" @default.
- W1519726308 modified "2023-10-16" @default.
- W1519726308 title "5 The Use of Embryonic Stem Cells for the Genetic Manipulation of the Mouse" @default.
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- W1519726308 doi "https://doi.org/10.1016/s0070-2153(08)60497-4" @default.
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