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• W1519800441 endingPage "5634" @default.
• W1519800441 startingPage "5623" @default.
• W1519800441 abstract "Two different states of human immunodeficiency virus type 1 are apparent in the asymptomatic and late stages of infection. Important determinants associated with these two states have been found within the V3 loop of the viral Env protein. In this study, two large data sets of published V3 sequences were analyzed to identify patterns of sequence variability that would correspond to these two states of the virus. We were especially interested in the pattern of basic amino acid substitutions, since the presence of basic amino acids in V3 has been shown to change virus tropism in cell culture. Four features of the sequence heterogeneity in V3 were observed: (i) approximately 70% of all nonconservative basic substitutions occur at four positions in V3, and V3 sequences with a basic substitution in at least one of these four positions contain approximately 95% of all nonconservative basic substitutions; (ii) substitution patterns within V3 are influenced by the identity of the amino acid at position 25; (iii) sequence polymorphisms account for a significant fraction of uncharged amino acid substitutions at several positions in V3, and sequence heterogeneity other than these polymorphisms is most significant at two positions near the tip of V3; and (iv) sequence heterogeneity in V3 (in addition to the basic amino acid substitutions) is approximately twofold greater in V3 sequences that contain basic amino acid substitutions. By using this sequence analysis, we were able to identify distinct groups of V3 sequences in infected patients that appear to correspond to these two virus states. The identification of these discrete sequence patterns in vivo demonstrates how the V3 sequence can be used as a genetic marker for studying the two states of human immunodeficiency virus type 1." @default.
• W1519800441 created "2016-06-24" @default.
• W1519800441 creator A5007433649 @default.
• W1519800441 creator A5029146792 @default.
• W1519800441 creator A5049756097 @default.
• W1519800441 date "1993-09-01" @default.
• W1519800441 modified "2023-09-26" @default.
• W1519800441 title "V3 loop of the human immunodeficiency virus type 1 Env protein: interpreting sequence variability" @default.
• W1519800441 cites W1497722057 @default.
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• W1519800441 cites W1523814949 @default.
• W1519800441 cites W1555021163 @default.
• W1519800441 cites W1568767105 @default.
• W1519800441 cites W1586699404 @default.
• W1519800441 cites W1607005809 @default.
• W1519800441 cites W1647969565 @default.
• W1519800441 cites W1659719610 @default.
• W1519800441 cites W1710012409 @default.
• W1519800441 cites W1723922714 @default.
• W1519800441 cites W1726325960 @default.
• W1519800441 cites W1739595091 @default.
• W1519800441 cites W1768734130 @default.
• W1519800441 cites W1773346304 @default.
• W1519800441 cites W1797550785 @default.
• W1519800441 cites W1836019507 @default.
• W1519800441 cites W1876598876 @default.
• W1519800441 cites W1900729316 @default.
• W1519800441 cites W1912026111 @default.
• W1519800441 cites W1918933327 @default.
• W1519800441 cites W1922162046 @default.
• W1519800441 cites W1938763205 @default.
• W1519800441 cites W1953822958 @default.
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• W1519800441 cites W1973013569 @default.
• W1519800441 cites W1974261771 @default.
• W1519800441 cites W1974416704 @default.
• W1519800441 cites W1976086277 @default.
• W1519800441 cites W1980259340 @default.
• W1519800441 cites W1982794770 @default.
• W1519800441 cites W1984416131 @default.
• W1519800441 cites W1986736371 @default.
• W1519800441 cites W1990765234 @default.
• W1519800441 cites W1995640420 @default.
• W1519800441 cites W1997321423 @default.
• W1519800441 cites W2000309384 @default.
• W1519800441 cites W2004617798 @default.
• W1519800441 cites W2005527330 @default.
• W1519800441 cites W2010258400 @default.
• W1519800441 cites W2014333265 @default.
• W1519800441 cites W2015777842 @default.
• W1519800441 cites W2021644405 @default.
• W1519800441 cites W2021984449 @default.
• W1519800441 cites W2022974362 @default.
• W1519800441 cites W2027112158 @default.
• W1519800441 cites W2044058829 @default.
• W1519800441 cites W2046790624 @default.
• W1519800441 cites W2048574795 @default.
• W1519800441 cites W2059599036 @default.
• W1519800441 cites W2066121768 @default.
• W1519800441 cites W2068490834 @default.
• W1519800441 cites W2069407559 @default.
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• W1519800441 cites W2071704136 @default.
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• W1519800441 cites W2088140730 @default.
• W1519800441 cites W2088403913 @default.
• W1519800441 cites W2091262391 @default.
• W1519800441 cites W2093251878 @default.
• W1519800441 cites W2106460806 @default.
• W1519800441 cites W2110917275 @default.
• W1519800441 cites W2112967927 @default.
• W1519800441 cites W2114279162 @default.
• W1519800441 cites W2128135205 @default.
• W1519800441 cites W2137966586 @default.
• W1519800441 cites W2152845055 @default.
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• W1519800441 cites W2323021547 @default.
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• W1519800441 doi "https://doi.org/10.1128/jvi.67.9.5623-5634.1993" @default.
• W1519800441 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/237966" @default.
• W1519800441 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8350415" @default.
• W1519800441 hasPublicationYear "1993" @default.
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