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• W1519839109 abstract "Inspiratory neurons of the preBötzinger complex (preBötC) form local excitatory networks and display 10–30 mV transient depolarizations, dubbed inspiratory drive potentials , with superimposed spiking. AMPA receptors are critical for rhythmogenesis under normal conditions in vitro but whether other postsynaptic mechanisms contribute to drive potential generation remains unknown. We examined synaptic and intrinsic membrane properties that generate inspiratory drive potentials in preBötC neurons using neonatal mouse medullary slice preparations that generate respiratory rhythm. We found that NMDA receptors, group I metabotropic glutamate receptors (mGluRs), but not group II mGluRs, contributed to inspiratory drive potentials. Subtype 1 of the group I mGluR family (mGluR1) probably regulates a K + channel, whereas mGluR5 operates via an inositol 1,4,5‐trisphosphate (IP 3 ) receptor‐dependent mechanism to augment drive potential generation. We tested for and verified the presence of a Ca 2+ ‐activated non‐specific cation current ( I CAN ) in preBötC neurons. We also found that high concentrations of intracellular BAPTA, a high‐affinity Ca 2+ chelator, and the I CAN antagonist flufenamic acid (FFA) decreased the magnitude of drive potentials. We conclude that I CAN underlies robust inspiratory drive potentials in preBötC neurons, and is only fully evoked by ionotropic and metabotropic glutamatergic synaptic inputs, i.e. by network activity." @default.
• W1519839109 created "2016-06-24" @default.
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• W1519839109 date "2007-06-25" @default.
• W1519839109 modified "2023-10-15" @default.
• W1519839109 title "Inspiratory bursts in the preBötzinger complex depend on a calcium‐activated non‐specific cation current linked to glutamate receptors in neonatal mice" @default.
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• W1519839109 doi "https://doi.org/10.1113/jphysiol.2007.133660" @default.
• W1519839109 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2075310" @default.
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