FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1519844080> ?p ?o ?g. }

• W1519844080 abstract "Background and purpose: Stromal cell derived factor 1 (SDF-1, also know as CXCL12) is a chemokine that can attract stem cells. We have shown that post-acute SDF1 gene therapy promoted angiogenesis and neurogenesis after ischemic stroke. Transplantation of endothelial progenitor cells (EPC) alone was also beneficial for ischemic stroke recovery. However, it remains unclear whether SDF-1 gene modification of EPC (EPC-SDF-1) can further promote stroke recovery. Here we used lenti-virus (LV) to deliver SDF-1 or GFP gene into EPC, then delivered gene modified EPC cells after permanent middle cerebral artery occlusion (MCAO) to investigate the effect of EPC-SDF-1 on ischemic stroke recovery. Methods and materials: Thirty-eight adult ICR male mice received EPC-SDF-1, EPC-GFP, LV-SDF-1, or PBS stereotactic injection into the peri-infarct area one week after MCAO. Brain atrophy volume, neurobehavioral tests and immunohistochemistry were performed to evaluate the effects of EPC-SDF-1 on angiogenesis and functional repair. Results: Brain atrophy volume was significantly reduced in both gene therapy and cell therapy groups 5 weeks after ischemia (p<0.05; LV-SDF-1 vs. PBS; EPC-GFP vs. PBS; EPC-SDF-1 vs. PBS; n=6), with a smaller atrophy volume in EPC-SDF-1 groups comparing to LV-SDF-1 (p<0.01) and EPC-GFP (p<0.001) group. Neurobehavioral tests including neurological deficits and rotarod test paralleled the result of atrophy volume, with neuronal function improved in all therapeutic groups 5 weeks after ischemic (p<0.001; LV-SDF-1 vs. PBS; EPC-GFP vs. PBS; EPC-SDF-1 vs. PBS; n=8-11), with a better outcome in EPC-SDF-1 group (EPC-SDF-1 vs. LV-SDF-1, p<0.05; EPC-SDF-1 vs. EPC-GFP, p<0.001). The number of CD31 positive blood vessels in peri-infarct area was significantly increased in LV-SDF-1 gene therapy (p<0.05, n=4) and EPC-SDF-1 cell therapy (p<0.001, n=4) group comparing to PBS control. Conclusion: Our results demonstrated that transplantation of SDF-1 gene modified EPC significantly increased angiogenesis after ischemic brain injury; reduced brain atrophy volume and improved the neurological outcomes of the animals. This in vivo data suggests that SDF-1 gene modification of EPC holds great potential in the treatment of ischemic stroke." @default.
• W1519844080 created "2016-06-24" @default.
• W1519844080 creator A5000793847 @default.
• W1519844080 creator A5013236283 @default.
• W1519844080 creator A5017164999 @default.
• W1519844080 creator A5044042665 @default.
• W1519844080 creator A5047097507 @default.
• W1519844080 creator A5069153972 @default.
• W1519844080 creator A5075063666 @default.
• W1519844080 creator A5086076274 @default.
• W1519844080 date "2015-02-01" @default.
• W1519844080 modified "2023-09-24" @default.
• W1519844080 title "Abstract 117: Stromal Cell-derived Factor-1 Gene Modified Endothelial Progenitor Cell Effectively Attenuated Ischemic Brain Injury in Mouse Model" @default.
• W1519844080 doi "https://doi.org/10.1161/str.46.suppl_1.117" @default.
• W1519844080 hasPublicationYear "2015" @default.
• W1519844080 type Work @default.
• W1519844080 sameAs 1519844080 @default.
• W1519844080 citedByCount "0" @default.
• W1519844080 crossrefType "journal-article" @default.
• W1519844080 hasAuthorship W1519844080A5000793847 @default.
• W1519844080 hasAuthorship W1519844080A5013236283 @default.
• W1519844080 hasAuthorship W1519844080A5017164999 @default.
• W1519844080 hasAuthorship W1519844080A5044042665 @default.
• W1519844080 hasAuthorship W1519844080A5047097507 @default.
• W1519844080 hasAuthorship W1519844080A5069153972 @default.
• W1519844080 hasAuthorship W1519844080A5075063666 @default.
• W1519844080 hasAuthorship W1519844080A5086076274 @default.
• W1519844080 hasConcept C104317684 @default.
• W1519844080 hasConcept C10882517 @default.
• W1519844080 hasConcept C111599444 @default.
• W1519844080 hasConcept C126322002 @default.
• W1519844080 hasConcept C127413603 @default.
• W1519844080 hasConcept C129470790 @default.
• W1519844080 hasConcept C13373296 @default.
• W1519844080 hasConcept C142724271 @default.
• W1519844080 hasConcept C16930146 @default.
• W1519844080 hasConcept C169760540 @default.
• W1519844080 hasConcept C201750760 @default.
• W1519844080 hasConcept C2776610909 @default.
• W1519844080 hasConcept C2776914184 @default.
• W1519844080 hasConcept C2778820722 @default.
• W1519844080 hasConcept C2780152582 @default.
• W1519844080 hasConcept C2780394083 @default.
• W1519844080 hasConcept C2780645631 @default.
• W1519844080 hasConcept C2781172350 @default.
• W1519844080 hasConcept C28328180 @default.
• W1519844080 hasConcept C2911091166 @default.
• W1519844080 hasConcept C4746552 @default.
• W1519844080 hasConcept C541997718 @default.
• W1519844080 hasConcept C55493867 @default.
• W1519844080 hasConcept C71924100 @default.
• W1519844080 hasConcept C78519656 @default.
• W1519844080 hasConcept C86803240 @default.
• W1519844080 hasConcept C95444343 @default.
• W1519844080 hasConceptScore W1519844080C104317684 @default.
• W1519844080 hasConceptScore W1519844080C10882517 @default.
• W1519844080 hasConceptScore W1519844080C111599444 @default.
• W1519844080 hasConceptScore W1519844080C126322002 @default.
• W1519844080 hasConceptScore W1519844080C127413603 @default.
• W1519844080 hasConceptScore W1519844080C129470790 @default.
• W1519844080 hasConceptScore W1519844080C13373296 @default.
• W1519844080 hasConceptScore W1519844080C142724271 @default.
• W1519844080 hasConceptScore W1519844080C16930146 @default.
• W1519844080 hasConceptScore W1519844080C169760540 @default.
• W1519844080 hasConceptScore W1519844080C201750760 @default.
• W1519844080 hasConceptScore W1519844080C2776610909 @default.
• W1519844080 hasConceptScore W1519844080C2776914184 @default.
• W1519844080 hasConceptScore W1519844080C2778820722 @default.
• W1519844080 hasConceptScore W1519844080C2780152582 @default.
• W1519844080 hasConceptScore W1519844080C2780394083 @default.
• W1519844080 hasConceptScore W1519844080C2780645631 @default.
• W1519844080 hasConceptScore W1519844080C2781172350 @default.
• W1519844080 hasConceptScore W1519844080C28328180 @default.
• W1519844080 hasConceptScore W1519844080C2911091166 @default.
• W1519844080 hasConceptScore W1519844080C4746552 @default.
• W1519844080 hasConceptScore W1519844080C541997718 @default.
• W1519844080 hasConceptScore W1519844080C55493867 @default.
• W1519844080 hasConceptScore W1519844080C71924100 @default.
• W1519844080 hasConceptScore W1519844080C78519656 @default.
• W1519844080 hasConceptScore W1519844080C86803240 @default.
• W1519844080 hasConceptScore W1519844080C95444343 @default.
• W1519844080 hasIssue "suppl_1" @default.
• W1519844080 hasLocation W15198440801 @default.
• W1519844080 hasOpenAccess W1519844080 @default.
• W1519844080 hasPrimaryLocation W15198440801 @default.
• W1519844080 hasRelatedWork W2000717335 @default.
• W1519844080 hasRelatedWork W2010160930 @default.
• W1519844080 hasRelatedWork W2046570577 @default.
• W1519844080 hasRelatedWork W2108856703 @default.
• W1519844080 hasRelatedWork W2132748062 @default.
• W1519844080 hasRelatedWork W2160525733 @default.
• W1519844080 hasRelatedWork W2161265223 @default.
• W1519844080 hasRelatedWork W2169427244 @default.
• W1519844080 hasRelatedWork W2354459773 @default.
• W1519844080 hasRelatedWork W2360941897 @default.
• W1519844080 hasRelatedWork W2372695007 @default.
• W1519844080 hasRelatedWork W2383693173 @default.
• W1519844080 hasRelatedWork W2767387205 @default.
• W1519844080 hasRelatedWork W2977958080 @default.
• W1519844080 hasRelatedWork W3028934872 @default.

• next